Synthesis and 3D Printing of biodegradable polyurethane elastomer by a water-based process for cartilage tissue engineering applications

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Title:	Synthesis and 3D Printing of biodegradable polyurethane elastomer by a water-based process for cartilage tissue engineering applications
Authors:	曾清秀;Hung, Kun-Che;Tseng, Ching-Shiow;Hsu, Shan-hui
Contributors:	工學院機械工程學系
Keywords:	3-D printers;3D printing;Animals;Biocompatibility;Biodegradability;Biodegradable materials;Biodegradable Plastics - chemistry;biodegradable polyurethane;Biological and medical sciences;Bioprinting - methods;Biotechnology;Cartilage - chemistry;Cartilage - cytology;Cartilage - metabolism;Cell Line;Cell Proliferation - physiology;Chondrocytes - cytology;Degradation;Dispersions;elasticity;Fundamental and applied biological sciences. Psychology;green process;Health. Pharmaceutical industry;Industrial applications and implications. Economical aspects;Medical sciences;Miscellaneous;Polyurethane resins;Polyurethanes - chemistry;Rats;scaffold;Scaffolds;Solvents;Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases;Technology. Biomaterials. Equipments;Tissue engineering;Tissue Engineering - instrumentation;Tissue Engineering - methods;Tissue Scaffolds
Date:	2014-10-01
Issue Date:	2026-04-23 15:29:06 (UTC+8)
Publisher:	John Wiley and Sons Ltd;Weinheim: Blackwell Publishing Ltd
Abstract:	摘要： Biodegradable materials that can undergo degradation in vivo are commonly employed to manufacture tissue engineering scaffolds, by techniques including the customized 3D printing. Traditional 3D printing methods involve the use of heat, toxic organic solvents, or toxic photoinitiators for fabrication of synthetic scaffolds. So far, there is no investigation on water‐based 3D printing for synthetic materials. In this study, the water dispersion of elastic and biodegradable polyurethane (PU) nanoparticles is synthesized, which is further employed to fabricate scaffolds by 3D printing using polyethylene oxide (PEO) as a viscosity enhancer. The surface morphology, degradation rate, and mechanical properties of the water‐based 3D‐printed PU scaffolds are evaluated and compared with those of polylactic‐co‐glycolic acid (PLGA) scaffolds made from the solution in organic solvent. These scaffolds are seeded with chondrocytes for evaluation of their potential as cartilage scaffolds. Chondrocytes in 3D‐printed PU scaffolds have excellent seeding efficiency, proliferation, and matrix production. Since PU is a category of versatile materials, the aqueous 3D printing process developed in this study is a platform technology that can be used to fabricate devices for biomedical applications. 其他題名： Adv. Healthcare Mater 出版者： Weinheim: Blackwell Publishing Ltd 出版日期： 2014-10 出處： Advanced Healthcare Materials, 2014-10, Vol.3 (10), p.1578-1587 資源來源： Wiley Online Library 版權： 2014 WILEY‐VCH Verlag GmbH & Co. KGaA, Weinheim 版權： 2015 INIST-CNRS 版權： 2014 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim. 版權： Copyright © 2014 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim 識別號： ISSN: 2192-2640 識別號： ISSN: 2192-2659 識別號： EISSN: 2192-2659 識別號： DOI: 10.1002/adhm.201400018 識別號： PMID: 24729580
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