Hydration of &quot;Nonfouling&quot; Functional Groups

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题名:	Hydration of ";Nonfouling";Functional Groups
作者:	Hower,JC;Bernards,MT;Chen,SF;Tsao,HK;Sheng,YJ;Jiang,SY
贡献者:	化學工程與材料工程學系
关键词:	SELF-ASSEMBLED MONOLAYERS;APPARENT MOLAL VOLUMES;PROTEIN ADSORPTION;ADIABATIC COMPRESSIBILITIES;MOLECULAR SIMULATION;SURFACE INTERACTIONS;AMINO-ACIDS;DYNAMICS;WATER;25-DEGREES-C
日期:	2009
上传时间:	2010-06-29 17:27:08 (UTC+8)
出版者:	中央大學
摘要:	The prevention of nonspecific protein adsorption to synthetic materials and devices presents a major design challenge in the biomedical community. While some chemical groups can resist nonspecific protein adsorption from simple solutions for limited contact times, there remains a need for new nonfouling functional groups and surface coatings that prevent protein adsorption from complex media like blood or in harsh environments like seawater. Recent studies of the molecular mechanisms of nonfouling surfaces have identified a strong correlation between surface hydration and resistance to nonspecific protein adsorption. In this work, we describe a simple experimental method for evaluating the intrinsic hydration capacity of model surface coating functional groups based on the partial molal volume at infinite dilution. In order to evaluate a range of hydration capacity and nonfouling performance, solutes were selected from three classes: ethylene glycols, sugar alcohols, and glycine analogues. The number of hydrating water molecules bound to a solute was estimated by comparing the molecular volume at infinite dilution to the Solute van der Waals molecular volume. The number of water molecules associated with each solute was further validated by constant pressure and temperature molecular dynamics simulations. Finally, a size-normalized molecular volume was correlated to previously observed protein adsorption experiments to relate the intrinsic hydration capacity of functional groups to their known nonfouling abilities.
關聯:	JOURNAL OF PHYSICAL CHEMISTRY B
显示于类别:	[化學工程與材料工程研究所] 期刊論文

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