Studies on epoxy compound fixation

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题名:	Studies on epoxy compound fixation
作者:	Sung,HW;Cheng,WH;Chiu,IS;Hsu,HL;Liu,SA
贡献者:	化學工程與材料工程學系
关键词:	HEART-VALVE BIOPROSTHESIS;GLUTARALDEHYDE;COLLAGEN;CALCIFICATION;BIOMATERIALS;PREVENTION;DERMATITIS;CONDUIT;GRAFTS
日期:	1996
上传时间:	2010-06-29 17:32:31 (UTC+8)
出版者:	中央大學
摘要:	Bioprostheses derived from collagenous tissues have to be fixed and subsequently sterilized before they can be implanted in humans, Clinically, the most commonly used fixative is glutaraldehyde, However, the tendency for glutaraldehyde to markedly alter tissue stiffness and promote tissue calcification are well-recognized drawbacks of this fixative. To address the deficiencies with the glutaraldehyde-fixed tissue, a new fixative, epoxy compound, was used to fix biological prostheses, The study was undertaken to investigate the fixation rates and crosslinking densities of biological tissues fixed with various epoxy compounds. These epoxy compounds are different in their chemical structures, Glutaraldehyde was used as a control, The fixation rates and crosslinking densities of the fixed tissues were determined by measuring their fixation indices and denaturation temperatures, respectively. Generally, the epoxy-fixed tissues were more pliable than the glutaraldehyde-fixed one. Furthermore, the tissues fixed with monofunctional epoxy compound were more pliable than those fixed with multifunctional epoxy compounds. With increasing pH or temperature, the fixation rate of epoxy compound increased, However, the number of epoxide functional groups did not seem to affect the fixation rate of the epoxy compound. The fixation rate of glutaraldehyde was faster than that of epoxy compounds, Additionally, the crosslinking density of the glutaraldehyde-fixed tissue was greater than that of the epoxy-fixed counterparts, Moreover, it was noted that the denaturation temperatures of the tissues fixed with glutaraldehyde or multifunctional epoxy compounds were significantly higher than the fresh ones (p <0.05), while that fixed with monofunctional epoxy compound stayed roughly the same throughout the entire fixation process (p >0.05). The results obtained in this study may be used to optimize the fixation process for developing bioprostheses fixed with epoxy compounds. (C) 1996 John Wiley & Sons, Inc.
關聯:	JOURNAL OF BIOMEDICAL MATERIALS RESEARCH
显示于类别:	[化學工程與材料工程研究所] 期刊論文

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