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    請使用永久網址來引用或連結此文件: http://ir.lib.ncu.edu.tw/handle/987654321/26855


    題名: Evaluation of chondrocyte growth in the highly porous scaffolds made by fused deposition manufacturing (FDM) filled with type II collagen
    作者: Yen,HJ;Tseng,CS;Hsu,SH;Tsai,CL
    貢獻者: 機械工程研究所
    關鍵詞: ARTICULAR-CARTILAGE REPAIR;IN-VITRO DEGRADATION;BIODEGRADABLE POLYESTERS;OSTEOCHONDRAL DEFECTS;MECHANICAL-PROPERTIES;HYBRID SPONGE;TISSUE;REGENERATION;ARCHITECTURE;MICROSPHERES
    日期: 2009
    上傳時間: 2010-06-29 18:01:47 (UTC+8)
    出版者: 中央大學
    摘要: Highly porous poly(d,l-lactide-co-glycolide) (PLGA) scaffolds for cartilage tissue engineering were fabricated in this study using the fused deposition manufacturing (FDM) process and were further modified by type II collagen. The average molecular weight of PLGA decreased to about 60% of the original value after the melt-extrusion process. Type II collagen exhibited sponge-like structure and filled the macroporous FDM scaffolds. An increase of the fiber spacing resulted in an increase of the porosity. The storage modulus of FDM scaffolds with a large fiber spacing was comparable to that of the native porcine articular cartilage. Although the FDM hybrid scaffolds were swollen in various extents after 28 days of in vitro culture, the seeded chondrocytes were well distributed in the interior of the scaffolds with a large fiber spacing and neocartilage was formed around the scaffolds. The study also suggested that a low processing temperature may be required to produce PLGA precision scaffolds using FDM.
    關聯: BIOMEDICAL MICRODEVICES
    顯示於類別:[機械工程研究所] 期刊論文

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