Inverse Symmetry in Complete Genomes and Whole-Genome Inverse Duplication

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题名:	Inverse Symmetry in Complete Genomes and Whole-Genome Inverse Duplication
作者:	Kong,SG;Fan,WL;Chen,HD;Hsu,ZT;Zhou,NJ;Zheng,B;Lee,HC
贡献者:	系統生物與生物資訊研究所
关键词:	STRAND COMPOSITIONAL ASYMMETRY;LONG NUCLEOTIDE-SEQUENCES;GENE DUPLICATION;COMPLEMENTARY STRANDS;BACTERIAL CHROMOSOMES;REPLICATION ORIGINS;DNA-SEQUENCES;EVOLUTION;BEAUTY;TRANSPOSITIONS
日期:	2009
上传时间:	2010-06-29 19:26:52 (UTC+8)
出版者:	中央大學
摘要:	The cause of symmetry is usually subtle, and its study often leads to a deeper understanding of the bearer of the symmetry. To gain insight into the dynamics driving the growth and evolution of genomes, we conducted a comprehensive study of textual symmetries in 786 complete chromosomes. We focused on symmetry based on our belief that, in spite of their extreme diversity, genomes must share common dynamical principles and mechanisms that drive their growth and evolution, and that the most robust footprints of such dynamics are symmetry related. We found that while complement and reverse symmetries are essentially absent in genomic sequences, inverse-complement plus reverse-symmetry is prevalent in complex patterns in most chromosomes, a vast majority of which have near maximum global inverse symmetry. We also discovered relations that can quantitatively account for the long observed but unexplained phenomenon of k-mer skews in genomes. Our results suggest segmental and whole-genome inverse duplications are important mechanisms in genome growth and evolution, probably because they are efficient means by which the genome can exploit its double-stranded structure to enrich its code-inventory.
關聯:	PLOS ONE
显示于类别:	[系統生物與生物資訊研究所] 期刊論文

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