Structure-Activity Relationship of New Anti-Hepatitis C Virus Agents: Heterobicycle-Coumarin Conjugates

Please use this identifier to cite or link to this item: http://ir.lib.ncu.edu.tw/handle/987654321/28339

Title:	Structure-Activity Relationship of New Anti-Hepatitis C Virus Agents: Heterobicycle-Coumarin Conjugates
Authors:	Neyts,J;De Clercq,E;Singha,R;Chang,YH;Das,AR;Chakraborty,SK;Hong,SC;Tsay,SC;Hsu,MH;Hwu,JR
Contributors:	中央大學
Keywords:	NS5B POLYMERASE;BENZIMIDAZOLE DERIVATIVES;BIOLOGICAL-ACTIVITY;ANTITUMOR-ACTIVITY;CELL-LINE;IN-VITRO;INHIBITORS;ANTICANCER;INFECTION;IDENTIFICATION
Date:	2009
Issue Date:	2010-06-29 19:46:28 (UTC+8)
Publisher:	化學研究所
Abstract:	For establishment of the structure-activity relationship, 19 heterobicycle-coumarin conjugated compounds with the -SCH2- linker were synthesized and found to possess significant antiviral activities. Prominent examples included imidazopyridine-coumarin 12c, purine-coumarin 12d, and benzoxazole-coumarin 14c, which inhibited HCV replication at an EC50 of 6.8, 2.0, and 12 mu M, respectively. The heteroatoms in bicycles
Relation:	JOURNAL OF MEDICINAL CHEMISTRY
Appears in Collections:	[Graduate Institute of Chemistry] journal & Dissertation

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