銅金屬催化碳-氧偶合反應路徑; Mechanism of Copper complexes as catalysts for C-O coupling reactions

Please use this identifier to cite or link to this item: https://ir.lib.ncu.edu.tw/handle/987654321/48032

Title:	銅金屬催化碳-氧偶合反應路徑;Mechanism of Copper complexes as catalysts for C-O coupling reactions
Authors:	陳弘杰;Hong-Jie Chen
Contributors:	化學研究所
Keywords:	碳-氧偶合反應;C-O coupling reaction
Date:	2011-07-20
Issue Date:	2012-01-05 14:27:44 (UTC+8)
Abstract:	碳-氧偶合反應在天然物和材料的合成方面有很好的應用性，因此科學家在近幾十年發表了無數篇的文獻。在本篇論文我們利用銅當作催化反應的過渡金屬分別在四個不同條件下進行反應，分別為CuI/phen/K2CO3, CuI/K2CO3, CuI/phen/Cs2CO3, CuI/Cs2CO3。接著我們希望能找出催化反應的中間物進而確認反應路徑，因此實驗室選擇使用ESI-MS 進行測量，最後再比較4-bromotoluene 和2-bromotoluene 選擇率確認我們測量出的結構是否符合。我們發現大部分科學家所推測的(phen)Cu(OR)中間物並不一定都是屬於主要反應路徑的起始結構。 C-O coupling reactions are widely used in natural products and materials synthesis, thus, in recent decades, scientists have reported numerous articles. In this article, we used copper as the transition metal to do catalytic reactions were carried out in four conditions which were CuI/phen/K2CO3, CuI/K2CO3, CuI/phen/Cs2CO3, CuI/Cs2CO3. After that we hope to find the intermediate of catalytic reactions and then confirm the reaction paths, thus, our lab choose to use the ESI-MS. Finally, comparing the selectivity of 4-bromotoluene and 2-bromotoluene confirmed the structures we measured by ESI-MS. We found that most scientists speculated the intermediate (phen)Cu(OR) doesn’t necessarily belong to the main catalytic reaction paths as starting structure.
Appears in Collections:	[Graduate Institute of Chemistry] Electronic Thesis & Dissertation

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