A systematic SPR study of human plasma protein adsorption behavior on the controlled surface packing of self-assembled poly(ethylene oxide) triblock copolymer surfaces

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Title:	A systematic SPR study of human plasma protein adsorption behavior on the controlled surface packing of self-assembled poly(ethylene oxide) triblock copolymer surfaces
Authors:	Chang,Y;Chu,WL;Chen,WY;Zheng,J;Liu,LY;Ruaan,RC;Higuchi,A
Contributors:	化學工程與材料工程學系
Keywords:	OXIDE)-POLY(PROPYLENE OXIDE)-POLY(ETHYLENE OXIDE);PLATELET-ADHESION;HYDROPHOBIC SURFACE;HEMATOPOIETIC STEM;STRONG RESISTANCE;BLOCK-COPOLYMERS;MONOLAYERS;RESONANCE;MICELLIZATION;PRESERVATION
Date:	2010
Issue Date:	2012-03-27 16:24:24 (UTC+8)
Publisher:	國立中央大學
Abstract:	A well-controlled biocompatible nonfouling surface is significant for biomedical requirements, especially for the improvement of biocompatibility. We demonstrate the low or nonbiofouling Surfaces by coating hydrophobic-hydrophobic triblock copolymers of poly(ethylene xide)-poly(propylene oxide)-poly(ethylene oxide) (PEO-PPO-PEO) on the CH(3)-terminated self-assembled monolayer (SAM). Two types of copolymers are Used to modify the surface, one with different PEO/PPO ratios (similar to 20/80, 40/60, and 80/20, w/w) but the same PPO molecular weight (similar to 2 k), the other with different copolymer MWs (similar to 9, 11, and 15 k) but the same PEO/PPO ratio (80/20, w/w). In situ surface plasmon resonance (SPR) sensor is used to evaluate polymer adsorption on the SAMs and subsequent protein adsorption on the copolymer-treated surface. The effects of PEO-PPO-PEO molecular weight, PPO-to-PEO ratio, and ionic strength on protein Adsorption from single protein solutions of fibrinogen, BSA, and complex mixed proteins are systematically investigated. A Pluronic (TM) F108 treated surface is highly resistant to nonspecific protein adsorption under the optimized conditions (MW of 15 k and PEO/PPO ratio of 80/20). This work demonstrates that the PEO-PPO-PEO polymer is able to achieve ultra low fouling surface via surface modification by Controlling surface packing density of polymers (molecular weight, hydrophobic/hydrophilic ratio, and hydrophilic group coverage). (C) 2009 Wiley Periodicals, Inc. J Biomed Mater Res 93A: 400-408, 2010
Relation:	JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART A
Appears in Collections:	[Department of Chemical and Materials Engineering] journal & Dissertation

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