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    Please use this identifier to cite or link to this item: http://ir.lib.ncu.edu.tw/handle/987654321/50646


    Title: Applying Harmonic Optical Microscopy for Spatial Alignment of Atrial Collagen Fibers
    Authors: Chiu,YW;Lo,MT;Tsai,MR;Chang,YC;Hsu,RB;Yu,HY;Sun,CK;Ho,YL
    Contributors: 數據分析方法研究中心
    Keywords: MITRAL-VALVE DISEASE;EXTRACELLULAR-MATRIX;2ND-HARMONIC GENERATION;FIBRILLATION;FIBROSIS;EXPRESSION;CARDIOMYOPATHY;ARRHYTHMIAS;MECHANISMS;FIBRILS
    Date: 2010
    Issue Date: 2012-03-27 17:50:06 (UTC+8)
    Publisher: 國立中央大學
    Abstract: Background: Atrial fibrosis creates a vulnerable tissue for atrial fibrillation (AF), but the spatial disarray of collagen fibers underlying atrial fibrosis is not fully elucidated. Objective: This study hypothesizes that harmonics optical microscopy can illuminate the spatial mal-alignment of collagen fibers in AF via a layer-by-layer approach. Patients and Methods: Atrial tissues taken from patients who underwent open-heart surgery were examined by harmonics optical microscopy. Using the two-dimensional Fourier transformation method, a spectral-energy description of image texture was constituted and its entropy was used to quantify the mal-alignment of collagen fibers. The amount of collagen fiber was derived from its area ratio to total atrial tissue in each image. Serum C-terminal pro-collagen pro-peptide (CICP), pro-matrix metalloproteinase-1 (pro-MMP-1), and tissue inhibitor of matrix metalloproteinase-1 (TIMP-1) were also evaluated. Results: 46 patients were evaluated, including 20 with normal sinus rhythm and 26 with AF. The entropy of spectral-energy distribution of collagen alignment was significantly higher in AF than that in sinus rhythm (3.97 +/- 0.33 vs. 2.80 +/- 0.18, p<0.005). This difference was more significant in the permanent AF group. The amount of collagen was also significantly higher in AF patients (0.39 +/- 0.13 vs. 0.18 +/- 0.06, p<0.005) but serum markers of cardiac fibrosis were not significantly different between the two groups. Conclusions: Harmonics optical microscopy can quantify the spatial mal-alignment of collagen fibers in AF. The entropy of spectral-energy distribution of collagen alignment is a potential tool for research in atrial remodeling.
    Relation: PLOS ONE
    Appears in Collections:[Research Center for adaptive Data analysis ] journal & Dissertation

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