Multiscale Entropy Analysis of Pulse Wave Velocity for Assessing Atherosclerosis in the Aged and Diabetic

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Title:	Multiscale Entropy Analysis of Pulse Wave Velocity for Assessing Atherosclerosis in the Aged and Diabetic
Authors:	Wu,HT;Hsu,PC;Lin,CF;Wang,HJ;Sun,CK;Liu,AB;Lo,MT;Tang,CJ
Contributors:	數據分析方法研究中心
Keywords:	ARTERIAL STIFFNESS;HEART-RATE;DYNAMICS;TIME;COMPLEXITY;RISK
Date:	2011
Issue Date:	2012-03-27 17:50:40 (UTC+8)
Publisher:	國立中央大學
Abstract:	This study proposed a dynamic pulse wave velocity (PWV)-based biomedical parameter in assessing the degree of atherosclerosis for the aged and diabetic populations. Totally, 91 subjects were recruited from a single medical institution between July 2009 and October 2010. The subjects were divided into four groups: young healthy adults (Group 1, n = 22), healthy upper middle-aged adults (Group 2, n = 28), type 2 diabetics with satisfactory blood sugar control (Group 3, n = 21), and unsatisfactory blood sugar control (Group 4, n = 20). A self-developed six-channel electrocardiography (ECG)-PWV-based equipment was used to acquire 1000 successive recordings of PWV(foot) values within 30 min. The data, thus, obtained were analyzed with multiscale entropy (MSE). Large-scale MSE index (MEI(LS)) was chosen as the assessment parameter. Not only did MEI(LS) successfully differentiate between subjects in Groups 1 and 2, but it also showed a significant difference between Groups 3 and 4. Compared with the conventional parameter of PWV(foot) and MEI on R-R interval [i.e., MEI (RRI)] in evaluating the degree of atherosclerotic change, the dynamic parameter, MEI(LS) (PWV), could better reflect the impact of age and blood sugar control on the progression of atherosclerosis.
Relation:	IEEE TRANSACTIONS ON BIOMEDICAL ENGINEERING
Appears in Collections:	[Research Center for adaptive Data analysis ] journal & Dissertation

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