Glycosylated nordihydroguaiaretic acids as anti-cancer agents

Please use this identifier to cite or link to this item: http://ir.lib.ncu.edu.tw/handle/987654321/50887

Title:	Glycosylated nordihydroguaiaretic acids as anti-cancer agents
Authors:	Hwu,JR;Hsu,CI;Hsu,MH;Liang,YC;Huang,RCC;Lee,YC
Contributors:	化學學系
Keywords:	O-6-METHYLGUANINE-DNA METHYLTRANSFERASE MGMT;ANTIVIRAL ACTIVITIES;TERMINAL ALKYNES;IN-VIVO;INHIBITION;EXPRESSION;TRANSCRIPTION;REPLICATION;DERIVATIVES;GROWTH
Date:	2011
Issue Date:	2012-03-27 18:12:12 (UTC+8)
Publisher:	國立中央大學
Abstract:	Three perglycosylated nordihydroguaiaretic acids (NDGA) were synthesized through the Huiseng 1,3-dipolar cycloaddition reaction. These sugar-NDGA conjugates containing triazole-linkages possessed good solubility in water. NDGA-(triazol-galactose)(4) (12b) and NDGA-(triazol-glucose)(4) (12c) were found to act as inhibitors against human hepatocellular carcinoma Hep3B cells in culture. (c) 2010 Published by Elsevier Ltd.
Relation:	BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
Appears in Collections:	[Department of Chemistry] journal & Dissertation

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