English  |  正體中文  |  简体中文  |  Items with full text/Total items : 70585/70585 (100%)
Visitors : 23114614      Online Users : 543
RC Version 7.0 © Powered By DSPACE, MIT. Enhanced by NTU Library IR team.
Scope Tips:
  • please add "double quotation mark" for query phrases to get precise results
  • please goto advance search for comprehansive author search
  • Adv. Search
    HomeLoginUploadHelpAboutAdminister Goto mobile version

    Please use this identifier to cite or link to this item: http://ir.lib.ncu.edu.tw/handle/987654321/51080

    Title: Universal Global Imprints of Genome Growth and Evolution - Equivalent Length and Cumulative Mutation Density
    Authors: Chen,HD;Fan,WL;Kong,SG;Lee,HC
    Contributors: 系統生物與生物資訊研究所
    Date: 2010
    Issue Date: 2012-03-27 18:20:50 (UTC+8)
    Publisher: 國立中央大學
    Abstract: Background: Segmental duplication is widely held to be an important mode of genome growth and evolution. Yet how this would affect the global structure of genomes has been little discussed. Methods/Principal Findings: Here, we show that equivalent length, or L(e), a quantity determined by the variance of fluctuating part of the distribution of the k-mer frequencies in a genome, characterizes the latter's global structure. We computed the L(e)s of 865 complete chromosomes and found that they have nearly universal but (k-dependent) values. The differences among the L(e) of a chromosome and those of its coding and non-coding parts were found to be slight. Conclusions: We verified that these non-trivial results are natural consequences of a genome growth model characterized by random segmental duplication and random point mutation, but not of any model whose dominant growth mechanism is not segmental duplication. Our study also indicates that genomes have a nearly universal cumulative "point'' mutation density of about 0.73 mutations per site that is compatible with the relatively low mutation rates of ( 1 similar to 5) x 10(-3)/site/Mya previously determined by sequence comparison for the human and E. coli genomes.
    Relation: PLOS ONE
    Appears in Collections:[系統生物與生物資訊研究所] 期刊論文

    Files in This Item:

    File Description SizeFormat

    All items in NCUIR are protected by copyright, with all rights reserved.

    社群 sharing

    ::: Copyright National Central University. | 國立中央大學圖書館版權所有 | 收藏本站 | 設為首頁 | 最佳瀏覽畫面: 1024*768 | 建站日期:8-24-2009 :::
    DSpace Software Copyright © 2002-2004  MIT &  Hewlett-Packard  /   Enhanced by   NTU Library IR team Copyright ©   - Feedback  - 隱私權政策聲明