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    题名: Modulating inhibitory control with direct current stimulation of the superior medial frontal cortex
    作者: Hsu,TY;Tseng,LY;Yu,JX;Kuo,WJ;Hung,DL;Tzeng,OJL;Walsh,V;Muggleton,NG;Juan,CH
    贡献者: 認知與神經科學研究所
    关键词: TRANSCRANIAL MAGNETIC STIMULATION;SUPPLEMENTARY MOTOR AREA;STOP-SIGNAL INHIBITION;DEFICIT HYPERACTIVITY DISORDER;INFERIOR PREFRONTAL CORTEX;EVENT-RELATED FMRI;RESPONSE-INHIBITION;COUNTERMANDING SACCADES;NEURONAL-ACTIVITY;ELECTRICAL-STIMULATION
    日期: 2011
    上传时间: 2012-03-27 18:21:58 (UTC+8)
    出版者: 國立中央大學
    摘要: The executive control of voluntary action involves not only choosing from a range of possible actions but also the inhibition of responses as circumstances demand. Recent studies have demonstrated that many clinical populations, such as people with attention-deficit hyperactivity disorder, exhibit difficulties in inhibitory control. One prefrontal area that has been particularly associated with inhibitory control is the pre-supplementary motor area (Pre-SMA). Here we applied non-invasive transcranial direct current stimulation (tDCS) over Pre-SMA to test its role in this behavior. tDCS allows for current to be applied in two directions to selectively excite or suppress the neural activity of Pre-SMA. Our results showed that anodal tDCS improved efficiency of inhibitory control. Conversely, cathodal tDCS showed a tendency towards impaired inhibitory control. To our knowledge, this is the first demonstration of non-invasive intervention tDCS altering subjects' inhibitory control. These results further our understanding of the neural bases of inhibitory control and suggest a possible therapeutic intervention method for clinical populations. (C) 2011 Elsevier Inc. All rights reserved.
    關聯: NEUROIMAGE
    显示于类别:[認知與神經科學研究所 ] 期刊論文

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