Characterization and prediction of mRNA polyadenylation sites in human genes

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题名:	Characterization and prediction of mRNA polyadenylation sites in human genes
作者:	Chang,TH;Wu,LC;Chen,YT;Huang,HD;Liu,BJ;Cheng,KF;Horng,JT
贡献者:	資訊工程學系
关键词:	SUPPORT VECTOR MACHINE;ALTERNATIVE POLYADENYLATION;PROCESSING EFFICIENCY;SEQUENCE ELEMENTS;SIGNALS;UPSTREAM;SECONDARY;DEGRADATION;MECHANISM;CLEAVAGE
日期:	2011
上传时间:	2012-03-27 18:57:41 (UTC+8)
出版者:	國立中央大學
摘要:	The accurate identification of potential poly(A) sites has contributed to all many studies with regard to alternative polyadenylation. The aim of this study was the development of a machine-learning methodology that will help to discriminate real polyadenylation signals from randomly occurring signals in genomic sequence. Since previous studies have revealed that RNA secondary structure in certain genes has significant impact, the authors tried to computationally pinpoint common structural patterns around the poly(A) sites and to investigate how RNA secondary structure may influence polyadenylation. This involved an initial study on the impact of RNA structure and it was found using motif search tools that hairpin structures might be important. Thus, it was propose that, in addition to the sequence pattern around poly(A) sites, there exists a widespread structural pattern that is also employed during human mRNA polyadenylation. In this study, the authors present a computational model that uses support vector machines to predict human poly(A) sites. The results show that this predictive model has a comparable performance to the current prediction tool. In addition, it was identified common structural patterns associated with polyadenylation using several motif finding programs and this provides new insight into the role of RNA secondary structure plays in polyadenylation.
關聯:	MEDICAL & BIOLOGICAL ENGINEERING & COMPUTING
显示于类别:	[資訊工程學系] 期刊論文

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