Strength of adhesion clusters under shared linear loading

Please use this identifier to cite or link to this item: http://ir.lib.ncu.edu.tw/handle/987654321/52978

Title:	Strength of adhesion clusters under shared linear loading
Authors:	Liang,HH;Chen,HY
Contributors:	物理學系
Keywords:	DYNAMIC FORCE SPECTROSCOPY;CHEMICAL-REACTIONS;CELL-ADHESION;BONDS;MODEL;SIMULATION;MOLECULES;KINETICS
Date:	2011
Issue Date:	2012-06-11 10:52:48 (UTC+8)
Publisher:	國立中央大學
Abstract:	A cluster of N ligand-receptor pairs between two parallel surfaces under an applied force F = Gamma t with a constant loading rate Gamma is considered. Our theoretical and numerical studies show that there is a characteristic force f(c) and a characteristic loading rate Gamma(c). At Gamma < Gamma(c), the mean rupture force F(r) of the cluster is close to but lower than Nf(c). In this regime, cluster dissociation can be modeled as a one-dimensional barrier crossing process and F(r) scales like Nf(c) - F(r) similar to N(1/3)[ln(Gamma(c)/Gamma)](2/3). At Gamma = Gamma(c), the cluster dissociation occurs at F(r) = Nf(c). At Gamma > Gamma(c), F(r) for clusters with large N is well predicted by the rate equation because the fluctuations of the number of closed bonds are unimportant. Our study shows that f(c) and Gamma(c) are important emergent properties for understanding the mechanical response of adhesion clusters.
Relation:	PHYSICAL REVIEW E
Appears in Collections:	[Department of Physics] journal & Dissertation

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