微型單光子放射電腦斷層掃描儀之系統開發與校準;Development and Calibration of a Pinhole Micro-SPECT System

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題名:	微型單光子放射電腦斷層掃描儀之系統開發與校準;Development and Calibration of a Pinhole Micro-SPECT System
作者:	陳怡君
貢獻者:	國立中央大學光電科學與工程學系
關鍵詞:	醫學工程;資訊科學;軟體
日期:	2012-12-01
上傳時間:	2014-03-17 11:51:54 (UTC+8)
出版者:	行政院國家科學委員會
摘要:	研究期間：10108~10207;Micro-SPECT along with small-animal models of human diseases is widely used in biomedical research to study disease mechanisms and investigate potential therapies. To improve the spatial resolution of SPECT systems, the researches and technologies based on pinhole imaging are discussed and developed successively. In this proposal, pinhole SPECT systems are the main imaging modality being considered. Generally, a nuclear medicine image system could be described as a linear digital-imaging system. The image vector is obtained by mapping the object function through the image reconstruction system matrix (IRSM). Therefore, the IRSM will influence the image quality directly, and the acquisition of IRSM with high precision and accuracy is essential for high-resolution image reconstructions. In this research, a method combined with experiments and simulations for fast generation of the IRSM with high preciseness is proposed. The IRSM will be generated with a geometric calibration experiment, a simplified 3D grid scanning experiment, and a Gaussian interpolation method combined with geometric parameter estimations. This method will be applied to create the IRSM of single-pinhole SPECT, multi-pinhole SPECT and dual-isotope SPECT, respectively. As dual-isotope SPECT possesses the advantage of significantly shorter acquisition time than generating images with individual isotopes and better patient comfort, the related researches and techniques are of increasing growth. However, the crosstalk contaminations of dual isotopes affect the image quality of respective isotopes and induce incorrect image information. In this investigation, a gamma camera module will be built with a symmetric charge division circuit, mean-detector-response-function measurements, and a maximum-likelihood position estimator. The projection data (blur functions and energy spectra) will be acquired from the homemade gamma camera module. The crosstalk contaminations of Compton scatters will be estimated and eliminated with a triple energy window method, and the compensation process of down scattering and Pb X-ray will be utilized to decrease the crosstalk effect. Subsequently, the image quality of individual isotopes will be improved to ensure the correctness of image information.
關聯:	財團法人國家實驗研究院科技政策研究與資訊中心
顯示於類別:	[光電科學與工程學系] 研究計畫

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