以X－光片層繞射技術研究膽固醇對脂膜的影響

Please use this identifier to cite or link to this item: http://ir.lib.ncu.edu.tw/handle/987654321/7194

Title:	以X－光片層繞射技術研究膽固醇對脂膜的影響
Authors:	賴元安;Yuan-An Lai
Contributors:	物理研究所
Date:	2001-07-19
Issue Date:	2009-09-22 10:51:59 (UTC+8)
Publisher:	國立中央大學圖書館
Abstract:	本論文利用X 光片層繞射/滲透壓技術，測量膽固醇在DLPC 脂膜的位置，並探討膽固醇對脂膜的抗滲透壓能力之影響。實驗結果顯示：（1）膽固醇存在於DLPC 脂膜厭水區；其分子長軸與脂質分子碳氫鏈軸大約平行；（2）膽固醇增加厭水區的平均厚度；（3）膽固醇減弱脂膜抗滲透壓。 We employed the technique of x-ray diffraction/osmotic pressure to measure the position of the cholesterol in bilayer structure and its modulus of compressibility for understanding the influence of the cholesterol on DLPC membrane. Results showed that : 1. Cholesterols reside in hydrophobic region of the DLPC membrane and its long molecular axis is parallel with the axis of phospolipid molecules ; 2. Cholesterols cause the DLPC membrane hydrophobic region thickening ; 3. Cholesterols reduce the modulus of DLPC bilayer compressibility.
Appears in Collections:	[Graduate Institute of Physics] Electronic Thesis & Dissertation

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