鈀金屬催化含氮炔類的合環反應之探討;Palladium catalyzed intramolecular cyclization of N-(2-ethynylcyclopentyl)sulfonamide

Please use this identifier to cite or link to this item: http://ir.lib.ncu.edu.tw/handle/987654321/74043

Title:	鈀金屬催化含氮炔類的合環反應之探討;Palladium catalyzed intramolecular cyclization of N-(2-ethynylcyclopentyl)sulfonamide
Authors:	詹詠翔;Chan, Yung-Hsiang
Contributors:	化學學系
Keywords:	鈀金屬催化含氮炔類的合環反應之探討
Date:	2017-08-23
Issue Date:	2017-10-27 13:00:26 (UTC+8)
Publisher:	國立中央大學
Abstract:	我們成功以鈀金屬催化含氮炔類化合物進行分子內合環形成環戊烷取代吡咯衍生物，且使用微波反應器輔助可以有效提升產率，最高可達92%。此方法可應用於合成藥物Ramipril 中的重要結構。;Hydroamination of N-(2-ethynylcyclopentyl)sulfonamide to give non-aromatic 2,3-dihydropyrroles was achieved by using PdCl2 as the catalyst. With microwave-assisted heating, up to 92% isolated yield was obtained from this intramolecular 5-endodig cyclization. The cyclopentane-fused 2,3-dihydropyrroles were transformed into the corresponding N-tosyl-pyrrolidine-2- carboxylic acids.
Appears in Collections:	[Graduate Institute of Chemistry] Electronic Thesis & Dissertation

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