我們提出了從各種藥物和劑型中回收有價值的原料藥（API）的方案，以便可以將其重新製備成新產品。藥物循環意味著將藥物中最重要的成分原料藥，透過分離賦形劑來回收純化得到產物(純API)。要完成目標最困難是大多數市售藥物不一定會標註產品的確切成分及含量，而有些藥物除了有其主要的API含量外，在其標籤上只會以賦形劑一項表示其他成分。因此，我們建立了藥物回收方案，無論藥物內的賦形劑含量為多少，設計出可以用於回收任何種類的原料藥之方法。為了測試其可行性，將此方案套用在回收我們自己配置的藥物(已知原料藥、賦形劑成分)。如果該方案被證明是可行的，那麼它將用於回收市售藥物以進一步證明該方案的可行性。我們將選擇回收的原料藥是：布洛芬(Ibuprofen)（一種抗炎藥），普羅布考(Probucol)（一種降膽固醇藥），四環素鹽酸鹽(Tetracycline HCl)（一種常見的抗生素）和三氧化二砷(Arsenic trioxide)（一種抗癌藥和白血病藥物）。所有回收的API的純度將通過FTIR、PXRD、DSC、UV-Vis光譜、1H NMR和HPLC鑑定。 ;We propose protocols to recycle valuable active pharmaceutical ingredients (APIs) from various kind of medications and dosage forms, so later it could be re-formulated as a new product. Drug recycle means that the most important component of the medication (the API) is recovered by separating it from the less important additives (the excipients). The difficulty in performing such task is most of commercial medications often do not show the exact compositions of the product, and some medicines even did not mention anything at all on its label, except for its main API content. Therefore, we established drug recycle protocols, which was designed so it can be used to recycle any kinds of API with similar properties, regardless of its excipient contents. To test its feasibility, the protocols will be tested to recycle our own pre-formulated drugs with known amount of excipients. If the protocol is proven to be feasible, then it will be used to recycle commercially available drugs to further prove the feasibility of the protocols. The APIs we will use as the drug models are: ibuprofen (an anti-inflammatory drug), probucol (a cholesterol-reducing drug), acetaminophen (a common painkiller), tetracycline HCl (a common antibiotic), and arsenic trioxide (an anti-cancer and leukemia drug). The purity of all recovered APIs will be verified by FTIR, PXRD, DSC, UV-Vis spectroscopy, 1H NMR, and HPLC.
