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    Please use this identifier to cite or link to this item: http://ir.lib.ncu.edu.tw/handle/987654321/79426

    Title: 磺基甜菜鹼基自組裝單分子層的形成、穩定性和抗污染性的比較研究;Comparative study in formation,stability and fouling resistance of sulfobetaine-based self-assembled monolayers
    Authors: 薩明;Ahmed, Mohamed Amin Salah Abbas Sayed
    Contributors: 生醫科學與工程學系
    Keywords: 磺酸甜菜鹼;抗吸附性;兩性離子自組裝單層;Sulfobetaine;fouling resistance;zwitterionic self-assembled monolayers
    Date: 2019-01-22
    Issue Date: 2019-04-02 14:24:21 (UTC+8)
    Publisher: 國立中央大學
    Abstract: 非特異性蛋白質吸附是生物醫學應用中最重要的問題,例如植入式
    基甜菜鹼基單體; (單硫醇)3 - [(11-巰基-十一烷基)-N,N-二
    甲基 - 氨基] - 丙烷-1-磺酸“SB-硫醇”,(二硫化物)硫辛酸 -
    磺基乙烷“SBSS”和(二硫醇)二氫脂質酸 - 磺基甜菜鹼“SB-二
    將SBSS 還原成SB-二硫醇導致更高的覆蓋率,對不同蛋白質的抗吸
    有望為未來的許多應用奠定基礎。;Non-specific protein adsorption is the most important problem in
    biomedical applications, such as implantable medical devices.1 In addition,
    the degradation of self-assembled monolayers has received a broad
    attention as it is regarded a key factor that determines the applicability of
    these systems into many applications. Many studies have been introduced
    to give stable coating materials with high fouling resistance against
    different blood components and different strategies have been proposed as
    a solution to enhance the stability of the self-assembled monolayers.2 In
    this work, we synthezied three sulfobetaine-based monomers; (monothiol)
    3-[(11-mercapto-undecyl)-N,N-dimethyl-amino]-propane-1-sulfonic acid
    “SB-thiol“, (disulfide) lipoic acid-sulfobetiane “SBSS“ and (dithiol)
    dihydrolipoic acid-sulfobetaine “SB-dithiol“, and compared the formation,
    stability and fouling resistance of their self-assembled monolayers. The
    reduction of SBSS into SB-dithiol3 resulted in a higher coverage, a better
    fouling resistance against different proteins, a higher capability to block
    electron transfer and an effective stability against desorption voltage sweep
    as was shown by the Surface Plasmon Resonance (SPR) formation test,
    protein fouling resistance test and the electrochemical analysis
    respectively. Although SB-dithiol exhibited a similar behavior to SB-thiol
    in the wetting properties and the fouling resistance against different
    proteins, the former showed a privilege in all the stability tests “contact
    angle analysis”, “thickness analysis”, “Surface Plasmon Resonance
    analysis” and electrochemical analysis. This study will develop our
    understanding of the interactions of analogues zwitterionic SAMs with
    gold and adjacent moities, and it is expected to put the basis for many future
    Appears in Collections:[生物醫學工程研究所 ] 博碩士論文

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