| 摘要: | 還原蝦紅素屬於類胡蘿蔔素，具有強抗氧化能力，但還原蝦紅素對光、熱、氧氣敏感，並且作為萜烯類，還原蝦紅素難溶於水，增加其在食品工業上使用的困難度。目前市售食入性產品多以油體共溶方式製成軟膠囊，此一劑型雖然具有一定的蝦紅素安定性，卻無法應用在更多元的食用商品。如何更高效的更有效的生產並保存蝦紅素，便成為一個重要關鍵。本研究擬利用微脂體(liposomes)對蝦紅素的包覆做研發，預期在微藻養殖生產與蝦紅素的保存上，有一系列完整的製程，以利相關保健食品、化妝品等多元應用。本計畫擬發展一套蝦紅素完整的生產供應鏈，打造台灣原創蝦紅素品牌，從微藻養殖到蝦紅素包覆保存，以供末端高價值商品應用，提升台灣生技產業整體競爭力，並與國際生物科技產業銜接。本計畫含括蝦紅素包覆技術的研究，將使用卵磷脂、膽固醇、天然乳化劑等天然食品級原料，利用原料的物理特性以及彼次之間的交連性來做蝦紅素的包覆測試。本計劃的研究主題包括： (i) 蝦紅素包覆技術開發, 利用磷脂質(phospholipid)或卵磷脂(Lecithin)進行蝦紅素包覆技術開發，進行配方設計，以粒徑，包覆率及含量分析篩選配方。(ii) 安定性分析：將未包覆和包覆顆粒之蝦紅素進行抗氧化能力分析，包覆之蝦紅素含有抗氧化能力≥60 %。(iii) 放大規模：先以小規模進行實驗，找出較佳之配方，然後進行放大規模測試。 ;Astaxanthin is a carotenoid and has strong antioxidant capacity. However, astaxanthin is sensitive to light, heat and oxygen. As a terpene, astaxanthin is difficult to dissolve in water, increasing its use in food industry. This research will focus on the encapsulation of astaxanthin using chitosan, phosphatidylcholines, phosphatidylethanolamines, phosphatidylserines, polysorbate, and cholesterol, etc. We will develop a process, which can improve not only the production of algaculture and the preservation of astaxanthin, this process will be used in industry in the near future in dietary supplement and cosmetics. This project aims to establish a complete astaxanthin production supply chain. It will not only enhance the competitiveness of Taiwan's biotechnology industry, but also link up with the international astaxanthin market. This project includes the research of liposome-encapsulated astaxanthin. We will use the natural food grade materials such as chitosan, phosphatidylcholines, phosphatidylethanolamines, phosphatidylserines, polysorbate, cholesterol, etc. as the encapsulating material. |
