高親水性聚醚醚酮-羥基磷灰石複合材料之椎間融合器的FDM列印路徑規劃及製造;FDM Printing Path Planning and Fabrication for Highly Hydrophilic PEEK-HA Interbody Cage

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题名:	高親水性聚醚醚酮-羥基磷灰石複合材料之椎間融合器的FDM列印路徑規劃及製造;FDM Printing Path Planning and Fabrication for Highly Hydrophilic PEEK-HA Interbody Cage
作者:	蔡鎮鴻;Tsai, Chen-Hung
贡献者:	機械工程學系
关键词:	椎間融合器;聚醚醚酮;積層製造技術;熔融沉積成型;表面改質;羥基磷灰石;親水性;Interbody cages;Polyetheretherketone;Additive Manufacturing;Fused Deposition Modeling;Surface Modification;Hydroxyapatite;Hydrophilicity
日期:	2024-07-10
上传时间:	2024-10-09 17:19:12 (UTC+8)
出版者:	國立中央大學
摘要:	椎間融合器是一種用於治療脊椎問題的醫療植入物，通常用於脊椎間的融合手術，以穩定脊椎體並促進骨頭的生長。近年來，聚醚醚酮(Polyetheretherketone, PEEK)作為一種高性能工程聚合物，因其優異的機械強度和生物相容性，被廣泛應用於椎間融合器的製造中。由於PEEK與皮質骨具有相似的彈性模量，因此它特別適合用於人體植入物的製造。然而，由於PEEK的生物惰性，其表面生物活性較差，這限制了其在骨整合和細胞黏附方面的性能。為了提高PEEK椎間融合器的生物活性，本研究採用熔融沉積成型技術製作PEEK椎間融合器，並通過列印路徑的規劃進行表面改質。在表面改質過程中，將羥基磷灰石(Hydroxyapatite, HA)添加到PEEK椎間融合器的表面，以增強其生物活性。透過多噴頭積層製造系統，將PEEK與PEEK-HA進行交互列印，使PEEK椎間融合器表面覆蓋一層PEEK-HA。接著，通過拉伸實驗分析表面改質後的機械強度變化，並進行親水性實驗以了解改質方法對親水性之影響。結果顯示，表面親水性隨著HA之比重增加而提升，最高可提升54.1%，能夠有效改善表面生物活性。 ;Interbody cages are medical implants used to treat spinal problems, typically employed in spinal fusion surgeries to stabilize vertebral bodies and promote bone growth. In recent years, Polyetheretherketone (PEEK), a high-performance engineering polymer, has been widely used in the manufacturing of interbody cages due to its excellent mechanical strength and biocompatibility. Because PEEK has a similar elastic modulus to cortical bone, it is particularly suitable for manufacturing implants for the human body. However, due to PEEK′s biological inertness, its surface bioactivity is relatively poor, limiting its performance in terms of bone integration and cell adhesion. To enhance the bioactivity of PEEK interbody cages, this study employed the technique of fused deposition modeling to manufacture PEEK interbody cages and performed surface modification through printing path planning. During the surface modification process, hydroxyapatite (HA) was added to the surface of PEEK interbody cages to enhance their bioactivity. Using a multi-nozzle layering system, PEEK and PEEK-HA were alternately printed, with a layer of PEEK-HA covering the surface of PEEK interbody cages. Subsequently, mechanical strength changes after surface modification were analyzed through tensile experiments, and hydrophilicity experiments were performed to understand the impact of the modification method on hydrophilicity. The results showed that surface hydrophilicity increased with the proportion of HA, achieving a maximum improvement of 54.1%, effectively enhancing surface bioactivity.
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