應用軟X光斷層掃描顯微術探討含硒藥物誘導結腸癌幹細胞類凋亡空泡化與粒線體-內質網壓力的三維立體型態變化及其在腫瘤類器官與PDX小鼠模式之分子機制研究;Three-Dimensional Morphological Changes of Selenium-Containing Drug-Induced Paraptotic Vacuolization and Mitochondrial-Er Stress in Colorectal Cancer Stem Cells Using Soft X-Ray Tomography and Molecular Mechanism Studies in Tumor Organoids and Pdx Mouse Models

NCUIR > college of Health Sciences and Technology > Department of Life Science > Research Project > Item 987654321/96750

Please use this identifier to cite or link to this item: http://ir.lib.ncu.edu.tw/handle/987654321/96750

Title:	應用軟X光斷層掃描顯微術探討含硒藥物誘導結腸癌幹細胞類凋亡空泡化與粒線體-內質網壓力的三維立體型態變化及其在腫瘤類器官與PDX小鼠模式之分子機制研究;Three-Dimensional Morphological Changes of Selenium-Containing Drug-Induced Paraptotic Vacuolization and Mitochondrial-Er Stress in Colorectal Cancer Stem Cells Using Soft X-Ray Tomography and Molecular Mechanism Studies in Tumor Organoids and Pdx Mouse Models
Authors:	羅月霞;林政鞍;林子敬
Contributors:	國立中央大學生命科學系
Keywords:	抗藥性;含硒藥物;粒線體;內質網;軟X射線斷層掃描;類凋亡;腫瘤類器官;人源性腫瘤細胞異種移殖;drug resistance;selenium drugs;mitochondria;ER;soft X-ray tomography;paraptosis;tumor organoid;patient-derived xenograft
Date:	2025-07-31
Issue Date:	2025-08-07 16:54:12 (UTC+8)
Publisher:	國家科學及技術委員會(本會)
Abstract:	臨床上仍然缺乏有效的結腸癌化療藥物，特別是解決抗藥性和復發問題。本計畫發現含硒藥物可能成為一種新型化療劑，透過特殊的細胞死亡機制（類凋亡，paraptosis）選擇性攻擊結腸癌細胞。本計畫將利用同步輻射中心的軟X射線斷層掃描（三維高解析細胞成像技術）和冷凍螢光影像技術，研究內質網和粒線體在含硒藥物作用下的精細形態變化，並利用腫瘤類器官模型與人源性腫瘤細胞異種移殖（PDX）模式，深入解析類凋亡的分子機制，為開發針對結腸癌的新型抗癌藥物提供關鍵理論基礎。
Relation:	財團法人國家實驗研究院科技政策研究與資訊中心
Appears in Collections:	[Department of Life Science] Research Project

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