以金屬有機骨架材料 MIL-53(Al) 結合分散式微固相萃取法檢測瓶裝茶飲中二苯甲酮類防曬乳成分殘留之研究

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题名:	以金屬有機骨架材料 MIL-53(Al) 結合分散式微固相萃取法檢測瓶裝茶飲中二苯甲酮類防曬乳成分殘留之研究
作者:	嵇鳳娟;Chi, Feng-Chuan
贡献者:	化學學系
关键词:	金屬有機骨架材料;分散式微固相萃取;新興汙染物;二苯甲酮類;防曬乳成分;Metal-organic framework;Dispersive micro-solid phase extraction;benzophenone-type ultraviolet filters
日期:	2025-06-18
上传时间:	2025-10-17 11:11:01 (UTC+8)
出版者:	國立中央大學
摘要:	本研究開發了一種簡單、環保的方法，用於快速檢測瓶裝茶飲樣品中的二苯甲酮類防曬乳成分 (benzophenone-type ultraviolet filters, 簡稱 BP-UVFs)。BP-UVFs 是一種新興污染物，存在於各種環境和生物樣本中，對公共衛生具有潛在風險，並可能在食物鏈中進行生物累積。以新興吸附劑金屬有機骨架 MIL-53(Al) 從瓶裝茶飲樣品中萃取五種 BP-UVFs 衍生物。MIL-53(Al) 具有高孔隙率、大表面積以及優異的化學和熱穩定性。此外，使用水作為溶劑來合成 MIL-53 (Al)，避免了有毒化學品，符合綠色分析化學的原則。採用分散微固相萃取法 (dispersive micro-solid phase extraction, 簡稱 D-μSPE) 從瓶裝茶飲樣品中萃取 BP-UVFs。採用 Box-Behnken Design 實驗設計最佳化 D-μSPE 的萃取條件，在提高效率的同時，最大程度地降低實驗成本和時間消耗。結合使用 UHPLC-電噴灑游離 (+) - 四極桿飛行時間質譜法對萃取的樣品進行定性和定量測定。所開發的方法經過充分驗證，顯示出低的定量極限 (LOQ；0.1 至 0.6 ng/mL)、令人滿意的平均回收率 (92 - 102%) 和高精密度 (RSD 小於3%)。此開發的方法被成功應用於瓶裝茶飲樣品中 BP-UVF 的測定。;In this study, we developed a simple and environmentally friendly method for quick detecting benzophenone-type ultraviolet filters (BP-UVFs) in bottled tea samples. BP-UVFs are a group of emerging contaminants, which found in various environmental and biota samples raising potential risks for public health concern and could bioaccumulate in the food chain. The emerging sorbent, metal-organic framework MIL-53(Al), was selected for extracting five BP-UVF derivatives from bottled tea samples. MIL-53(Al) provides high porosity, large surface area, and excellent chemical and thermal stability. Moreover, water was used as the solvent to synthesize MIL-53(Al), avoiding toxic chemicals and aligning with the principles of green analytical chemistry. Dispersive micro-solid phase extraction (D-μSPE) method was employed to extract BP-UVFs from bottled tea samples. Box-Behnken experimental design (BBD) was applied to optimize extraction conditions for D-μSPE, which enhances efficiency while minimizing experimental costs and time consumption. The extracted samples were then analyzed using UHPLC-electrospray ionization (+) - quadrupole time-of-flight mass spectrometry for qualitative and quantitative determination. The developed method was fully validated, showing low limits of quantification (LOQs; 0.1 to 0.6 ng/mL), satisfactory mean spiked recoveries (92 - 102%), and a high level of precision (RSD less than 3%). The developed method was then successfully applied for the determination of BP-UVFs in bottled tea samples.
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