設計與合成應用於硫化氫檢測的1,2,3-三嗪螢光響應探針;Design and Synthesis of 1,2,3-Triazine-based Fluorogenic Probes for Hydrogen Sulfide Detection

NCU Institutional Repository > 理學院 > 化學研究所 > 博碩士論文 > Item 987654321/97562

jsp.display-item.identifier=請使用永久網址來引用或連結此文件: https://ir.lib.ncu.edu.tw/handle/987654321/97562

题名:	設計與合成應用於硫化氫檢測的1,2,3-三嗪螢光響應探針;Design and Synthesis of 1,2,3-Triazine-based Fluorogenic Probes for Hydrogen Sulfide Detection
作者:	許喆俞;Hsu, Che-Yu
贡献者:	化學學系
关键词:	硫化氫檢測;螢光探針;1,2,3-三嗪;二氟化硼二吡咯亞甲基;hydrogen sulfide detection;fluorogenic probes;1,2,3-triazine;BODIPY
日期:	2025-08-20
上传时间:	2025-10-17 11:36:55 (UTC+8)
出版者:	國立中央大學
摘要:	最近的研究表明，硫化氫生成酶在癌細胞中選擇性過度表達，導致細胞內硫化氫濃度高於正常細胞。這一現象顯示硫化氫有可能作為區分癌細胞和正常細胞的生物標記。本研究中，我們設計並合成了一系列基於1,2,3-三嗪的螢光探針用於檢測硫化氫，這些探針利用1,2,3-三嗪作為螢光猝滅劑，並與硫化氫反應，重啟發光團BODIPY基團的螢光放射。在一系列合成的三嗪螢光響應探針: 3-Tz-H、3-Tz-Et、8-Tz-H及8-Tz-Et與硫化鈉反應後，產生明顯的螢光強度差異，表明它們對硫化氫具有有效的反應。這些結果表明，基於1,2,3-三嗪設計的螢光探針有望用於檢測癌細胞中的硫化氫的潛力。;Recent studies have indicated that the hydrogen sulfide-producing enzymes are selectively overexpressed in cancer cells, resulting in elevated intracellular H2S concentrations compared to those in normal cells. This phenomenon suggests that H₂S has the potential to serve as a biomarker for distinguishing cancer cells from their normal counterparts. In this study, we designed and synthesized a series of 1,2,3-triazine-based fluorogenic probes for H2S detection. These probes utilize 1,2,3-triazine as a fluorescence quencher, which reacts with H2S to trigger the emission of the fluorophore BODIPY. Among the synthesized probes, 3-Tz-H, 3-Tz-Et, 8-Tz-H, and 8-Tz-Et exhibited significant fluorescence enhancement upon reaction with sodium sulfide, indicating an effective response to H2S. These findings suggest that 1,2,3-triazine-based fluorogenic probes hold promise for detecting H2S in cancer cells.
显示于类别:	[化學研究所] 博碩士論文

文件中的档案:

档案	描述	大小	格式	浏览次数
index.html		0Kb	HTML	3	检视/开启

在NCUIR中所有的数据项都受到原著作权保护.

社群 sharing

数据加载中.....