Novel Trimethylamine N-oxide-Based Zwitterionic Hydrogels for Biomedical Application

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Title:	Novel Trimethylamine N-oxide-Based Zwitterionic Hydrogels for Biomedical Application
Authors:	黎玉揚;Ngang, Le Thi Ngoc
Contributors:	化學工程與材料工程學系
Keywords:	One keyword per line;抗凍性;生物相容性;生物標記;交聯劑;兩性離子水凝膠;One keyword per line;Anti-freezing;biocompatibility;biotag;crosslinker;zwitterionic hydrogel
Date:	2026-01-28
Issue Date:	2026-03-06 18:22:36 (UTC+8)
Publisher:	國立中央大學
Abstract:	由於具有高水合性、電荷中性以及優異的抗污行為，兩性離子水凝膠近年來在生醫材料、抗污塗層與生物感測器等領域受到廣泛關注。兩性離子材料能與水分子形成強烈作用並有效結合水分子，使其即使在複雜環境條件下，仍能展現優異的含水能力與抗污特性。在眾多兩性離子材料中，三甲胺N-氧化物（Trimethylamine N-oxide, TMAO）是一種天然存在於極端環境海洋生物中的滲透調節物質，因其獨特的水合行為與抗污特性，近年來引起研究者的高度關注。本論文提出一種完全以 TMAO 為基礎的兩性離子水凝膠，其由海鮮來源之 TMAO 單體與一種新穎且特別設計的兩性離子交聯劑——氧化甲基雙（ 2- 丙烯酰氧基乙基）胺（ Methyl-bis(2-acryloyloxyethyl)amine oxide, NOBA）所合成。該水凝膠展現良好的機械穩定性、優異的耐離子強度能力、卓越的抗污性能以及良好的抗凍特性，這些特性可歸因於強烈的水–聚合物交互作用以及水凝膠網絡中水分狀態的有效調控。此外，初步研究結果顯示，TMAO 水凝膠在魚類腐敗偵測方面具有潛在的生物標記應用價值，其特徵表現為水凝膠隨腐敗過程產生明顯膨潤並伴隨顏色變化，顯示其在食品安全生物感測領域具有良好的應用前景。;With the characteristics of increased hydration, charge neutrality, and strong antifouling behavior, zwitterionic hydrogels have attracted growing interest for use in biomedical materials, antifouling coatings, and biosensors. The unique ability of zwitterionic materials to interact with and bind water molecules leads to enhanced water retention and antifouling properties, even under complex environmental conditions. Among zwitterionic materials, trimethylamine N-oxide (TMAO), a naturally derived osmolyte found in marine organisms living in extreme conditions, has attracted interest in recent years due to its unique hydration and antifouling properties. This thesis presents the preparation of a fully TMAO-based zwitterionic hydrogel synthesized from a seafood-derived TMAO monomer and a novel, specifically designed zwitterionic cross-linker, Methyl-bis(2-acryloyloxyethyl)amine oxide (NOBA). This hydrogel exhibits favorable mechanical stability, strong resistance to ionic strength, excellent antifouling attributes, and good anti-freezing properties, which can be ascribed to the strong water-polymer interactions as well as the water state control in the hydrogel network. In addition, the initial results indicate that the TMAO hydrogel exhibits promising bio-tagging properties for detecting fish spoilage, as evidenced by visible expansion and color changes, suggesting strong potential for bio-sensing in food safety.
Appears in Collections:	[National Central University Department of Chemical & Materials Engineering] Electronic Thesis & Dissertation

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