In vitro toxicology of ambient particulate matter: Correlation of cellular effects with particle size and components

NCUIR > College of Earth Sciences > Department of Atmospheric Sciences > journal & Dissertation > Item 987654321/99864

Please use this identifier to cite or link to this item: https://ir.lib.ncu.edu.tw/handle/987654321/99864

Title:	In vitro toxicology of ambient particulate matter: Correlation of cellular effects with particle size and components
Authors:	柯奧圖;Kroll, Alexandra;Gietl, Johanna K.;Wiesmüller, Gerhard A.;Günsel, Andreas;Wohlleben, Wendel;Schnekenburger, Jürgen;Klemm, Otto
Contributors:	地球科學學院大氣科學學系
Keywords:	Air Pollutants;Air Pollutants - toxicity;Airborne particulates;Ammonium;Animal, plant and microbial ecology;Animals;Applied ecology;at-risk population;Atoms & subatomic particles;Biological and medical sciences;Caco-2 Cells;chemical elements;Chloride-Bicarbonate Antiporters;Chloride-Bicarbonate Antiporters - toxicity;correlation;Dogs;drug effects;Ecotoxicology, biological effects of pollution;endotoxin;Endotoxins;Endotoxins - toxicity;Fundamental and applied biological sciences. Psychology;General aspects;Germany;Humans;in vitro toxicity;inflammation;Madin Darby Canine Kidney Cells;metabolism;Metals;Metals - toxicity;Mice;morbidity;mortality;Nitrates;Nitrates - toxicity;Oxidative stress;Oxidative Stress - drug effects;Particle Size;Particulate Matter;Particulate Matter - toxicity;particulates;Quaternary Ammonium Compounds;Quaternary Ammonium Compounds - toxicity;reactive oxygen species;Reactive Oxygen Species - metabolism;size distribution;Sulfates;Sulfates - toxicity;toxicity;Toxicology
Date:	2013-02-01
Issue Date:	2026-04-21 13:38:48 (UTC+8)
Publisher:	John Wiley and Sons Inc.;Hoboken: Wiley Subscription Services, Inc., A Wiley Company
Abstract:	摘要： High concentrations of airborne particulate matter (PM) have been associated with increased rates of morbidity and mortality among exposed populations. Although certain components of PM were suggested to influence these effects, no clear‐cut correlation was determined thus far. One of the possible modes of action is the induction of oxidative stress by inhaled PM triggering inflammatory responses. Therefore, the in vitro formation of reactive oxygen species (ROS) in three cell lines in the presence of five subfractions of PM10, collected in Münster, Germany was investigated. The PM components chloride, nitrate, ammonium, sulfate, 68 chemical elements, and endotoxin were quantified. The highest concentration of endotoxin was found in particles of 0.42–1.2 μm aerodynamic diameters, and therefore probably subject to long‐range transport. Intracellular ROS formation in three well established mammalian cell lines (CaCo2, human; MDCK, canine; RAW264.7, mouse) only correlated positively with particle size. The two smallest PM size fractions provoked the highest rise in ROS. However, the latter did not correlate with the concentration of any PM components investigated. The smallest PM size fractions significantly dominated the number of particles. Therefore, the particle number may be most effective in inducing oxidative stress in vitro. © 2011 Wiley Periodicals, Inc. Environ Toxicol, 2013. 其他題名： Environ. Toxicol 出版者： Hoboken: Wiley Subscription Services, Inc., A Wiley Company 出版日期： 2013-02 出處： Environmental toxicology, 2013-02, Vol.28 (2), p.76-86 資源來源： Wiley Online Library - AutoHoldings Journals 版權： Copyright © 2011 Wiley Periodicals, Inc. 版權： 2014 INIST-CNRS 識別號： ISSN: 1520-4081 識別號： ISSN: 1522-7278 識別號： EISSN: 1522-7278 識別號： DOI: 10.1002/tox.20699 識別號： PMID: 21384498 識別號： CODEN: ETOXFH
Appears in Collections:	[Department of Atmospheric Sciences] journal & Dissertation

Files in This Item:

File	Description	Size	Format
index.html		0Kb	HTML	19	View/Open

社群 sharing

Loading...