| 摘要: | 摘要： A sequence of vinylalumination of α‐substituted aldehydes, ring‐closing metathesis (RCM), and palladium‐catalyzed allylic substitution was utilized to prepare the biologically active natural products, pericosines, from d‐ribose. The anti‐adduct of vinylalumination was transformed into pericosine A after RCM, removal of the 4‐methoxybenzyl protecting group, and chlorination. The diacetate of the anti‐adduct was converted to pericosine C after the palladium‐catalyzed, SN2′‐type, allylic substitution. However, an unexpected dimeric product was generated in utilizing this approach to prepare pericosine E. Pericosines A, C, and E: A sequence of vinylalumination of α‐substituted aldehydes, ring‐closing metathesis, and palladium‐catalyzed allylic substitution was utilized to prepare the biologically active natural products, pericosines, from d‐ribose.
其他題名： Asian J. Org. Chem
出版者： Weinheim: Blackwell Publishing Ltd
出版日期： 2016-11
出處： Asian journal of organic chemistry, 2016-11, Vol.5 (11), p.1327-1333
版權： 2016 Wiley‐VCH Verlag GmbH & Co. KGaA, Weinheim
版權： 2016 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim
識別號： ISSN: 2193-5807
識別號： EISSN: 2193-5815
識別號： DOI: 10.1002/ajoc.201600355 |
