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| 題名: | IL-8 induces miR-424-5p expression and modulates SOCS2/STAT5 signaling pathway in oral squamous cell carcinoma |
| 作者: | 金秀蓮;Peng, Hsuan-Yu;Jiang, Shih-Sheng;Hsiao, Jenn-Ren;Hsiao, Michael;Hsu, Yuan-Ming;Wu, Guan-Hsun;Chang, Wei-Min;Chang, Jang-Yang;Jin, Shiow-Lian Catherine;Shiah, Shine-Gwo |
| 貢獻者: | 生醫理工學院生命科學系 |
| 關鍵詞: | Binding sites;Cancer therapies;Carcinoma, Squamous Cell - genetics;Carcinoma, Squamous Cell - metabolism;Carcinoma, Squamous Cell - pathology;Cell adhesion & migration;Cell growth;Cell Line, Tumor;Cell migration;Cell Movement;Cytokines;Epidermal growth factor;Feedback;Gene expression;Gene Expression Regulation, Neoplastic;Humans;IL-8;Interleukin-8 - metabolism;Invasion;Invasiveness;Janus kinase;Kinases;Matrix metalloproteinase;microRNA;MicroRNAs;MicroRNAs - genetics;MicroRNAs - metabolism;Mouth - metabolism;Mouth - pathology;Mouth Neoplasms - genetics;Mouth Neoplasms - metabolism;Mouth Neoplasms - pathology;Neoplasm Invasiveness - genetics;Neoplasm Invasiveness - pathology;Oral cancer;Oral squamous cell carcinoma;Phosphorylation;Proteins;Signal Transduction;SOCS2;Squamous cell carcinoma;Stat5 protein;STAT5 Transcription Factor - metabolism;Suppressor of Cytokine Signaling Proteins - genetics;Suppressor of Cytokine Signaling Proteins - metabolism;Transcription |
| 日期: | 2016-06-01 |
| 上傳時間: | 2026-04-23 11:13:04 (UTC+8) |
| 出版者: | John Wiley and Sons Ltd;United States: Elsevier B.V |
| 摘要: | 摘要： Suppressor of cytokine signaling (SOCS) proteins are negative feedback regulators of the Janus kinase/signal transducer and activator of transcription (JAK/STAT) pathway. Dysregulation of SOCS protein expression in cancers can be one of the mechanisms that maintain STAT activation, but this mechanism is still poorly understood in oral squamous cell carcinoma (OSCC). Here, we report that SOCS2 protein is significantly downregulated in OSCC patients and its levels are inversely correlated with miR-424-5p expression. We identified the SOCS2 protein, which modulates STAT5 activity, as a direct target of miR-424-5p. The miR-424-5p-induced STAT5 phosphorylation, matrix metalloproteinases (MMPs) expression, and cell migration and invasion were blocked by SOCS2 restoration, suggesting that miR-424-5p exhibits its oncogenic activity through negatively regulating SOCS2 levels. Furthermore, miR-424-5p expression could be induced by the cytokine IL-8 primarily through enhancing STAT5 transcriptional activity rather than NF-κB signaling. Antagomir-mediated inactivation of miR-424-5p prevented the IL-8-induced cell migration and invasion, indicating that miR-424-5p is required for IL-8-induced cellular invasiveness. Taken together, these data indicate that STAT5-dependent expression of miR-424-5p plays an important role in mediating IL-8/STAT5/SOCS2 feedback loop, and scavenging miR-424-5p function using antagomir may have therapeutic potential for the treatment of OSCC. •miR-424-5p is overexpressed in OSCC.•miR-424-5p directly targets SOCS2, leading to increased cell migration and invasion.•STAT5 activation is required for IL-8-mediated miR-424-5p transcription.•miR-424-5p plays an important role in mediating IL-8/STAT5/SOCS2 feedback loop.
其他題名： Mol Oncol
出版者： United States: Elsevier B.V
出版日期： 2016-06
出處： Molecular Oncology, 2016-06, Vol.10 (6), p.895-909
資源來源： ScienceDirect (Elsevier) Journals
版權： 2016 The Authors
版權： 2016 The Authors. Published by FEBS Press and John Wiley ' Sons Ltd.
版權： Copyright © 2016 The Authors. Published by Elsevier B.V. All rights reserved.
版權： 2016. This work is published under http://creativecommons.org/licenses/by-nc-nd/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.
識別號： ISSN: 1574-7891
識別號： ISSN: 1878-0261
識別號： EISSN: 1878-0261
識別號： DOI: 10.1016/j.molonc.2016.03.001
識別號： PMID: 27038552 |
| 顯示於類別: | [生命科學系] 期刊論文
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