SNP rs4331426 in 18q11.2 is associated with susceptibility to tuberculosis among female Han Taiwanese

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題名:	SNP rs4331426 in 18q11.2 is associated with susceptibility to tuberculosis among female Han Taiwanese
作者:	高永旭;Lee, Shih-Wei;Lin, Chia-Yin;Chuang, Tzu-Yi;Huang, Hsiu-Han;Kao, Yung-Hsi;Wu, Lawrence Shih-Hsin
貢獻者:	生醫理工學院生命科學系
關鍵詞:	Asian Continental Ancestry Group - genetics;Case-Control Studies;Chromosomes, Human, Pair 18 - genetics;Female;Gene Frequency - genetics;Genetic Predisposition to Disease;Genome-Wide Association Study;Genotype;Humans;Infectious Disease;Male;Medical Education;Mycobacterium;Polymorphism, Single Nucleotide - genetics;rs4331426;single nucleotide polymorphism;Taiwan;tuberculosis;Tuberculosis, Pulmonary - genetics;Tuberculosis, Pulmonary - microbiology
日期:	2016-06-01
上傳時間:	2026-04-23 11:13:46 (UTC+8)
出版者:	Elsevier Taiwan LLC;England: Elsevier B.V
摘要:	摘要： A single nucleotide polymorphism (SNP) rs4331426 located in a gene-poor region on chromosome 18q11.2 has been associated with tuberculosis (TB) by genome-wide association studies in Ghana and Gambia. In this study, we analyzed the SNP rs4331426 for its association with the risk of TB in the Taiwanese population. The SNP rs4331426 was genotyped in a case-control design that included 377 Han Taiwanese (200 TB patients and 177 controls) and was associated with TB (marginally significant p = 0.078). An increasingly significant association was observed after adjusting for sex in the logistic regression analysis (p = 0.029). Furthermore, the G carrier (AG genotype) conferred the risk of TB in females (p = 0.011), but not in males. These findings indicate that the SNP rs4331426 associated with TB in the Han Taiwanese population, especially in females. Further investigations on its role and that of the genomic region surrounding it are warranted. 其他題名： J Microbiol Immunol Infect 出版者： England: Elsevier B.V 出版日期： 2016-06-01 出處： Journal of microbiology, immunology and infection, 2016-06, Vol.49 (3), p.436-438 資源來源： Elsevier ScienceDirect Journals Complete 版權： 2015 版權： Copyright © 2015. Published by Elsevier B.V. 識別號： ISSN: 1684-1182 識別號： ISSN: 1995-9133 識別號： EISSN: 1995-9133 識別號： DOI: 10.1016/j.jmii.2014.11.007 識別號： PMID: 25648838
顯示於類別:	[生命科學系] 期刊論文

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