摘要： Resistance of cancer cells to chemotherapy and/or radiotherapy is a major challenge to current anticancer treatment. The NF-κB signaling pathway plays an important role in tumor development and progression, and results in unsatisfactory treatment outcome. Inhibition of the NF-κB signaling cascade may sensitize the resistant cancer cells to chemotherapy and/or radiotherapy. Here, the correlation of NF-κB molecules with carcinogenesis and tumor progression, along with its significance in clinical practice, is reviewed. The potential clinical application of NF-κB and its associated molecules as diagnostic and therapeutic targets is also discussed. 其他題名： Expert Rev Mol Diagn 出版者： England: Taylor & Francis 出版日期： 2012-03-01 出處： Expert review of molecular diagnostics, 2012-03, Vol.12 (2), p.139-146 版權： Expert Reviews Ltd 2012 識別號： ISSN: 1473-7159 識別號： ISSN: 1744-8352 識別號： EISSN: 1744-8352 識別號： DOI: 10.1586/erm.12.2 識別號： PMID: 22369374
