VAV3 oncogene expression in colorectal cancer: Clinical aspects and functional characterization

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題名:	VAV3 oncogene expression in colorectal cancer: Clinical aspects and functional characterization
作者:	王陸海;Uen, Yih-Huei;Fang, Chia-Lang;Hseu, You-Cheng;Shen, Pei-Chun;Yang, Hsin-Ling;Wen, Kuo-Shan;Hung, Shih-Ting;Wang, Lu-Hai;Lin, Kai-Yuan
貢獻者:	生醫理工學院生命科學系
關鍵詞:	1-Phosphatidylinositol 3-kinase;13/31;13/51;13/89;38/88;38/90;692/308/1892;692/308/575;692/53/2422;82/80;AKT protein;Cell cycle;Clinical aspects;Colorectal cancer;Colorectal Neoplasms - genetics;Colorectal Neoplasms - pathology;Humanities and Social Sciences;Humans;Medical prognosis;Metastases;Metastasis;multidisciplinary;Oncogenes;Proto-Oncogene Proteins c-vav - genetics;Regression analysis;Science;Signal transduction;Xenografts
日期:	2015-01-01
上傳時間:	2026-04-23 11:14:20 (UTC+8)
出版者:	Nature Publishing Group;London: Nature Publishing Group UK
摘要:	摘要： Although colorectal cancer (CRC) is one of the most common malignancies worldwide, the current therapeutic approaches for advanced CRC are ineffective. In this study, we investigated the involvement of the VAV3 oncogene in tumor progression and in the prognosis of human CRC. The two patient cohorts in this study comprised 354 CRC cases from 1998 to 2005 with documented pathologic and clinical factors and clinical outcomes. VAV3 protein levels were significantly correlated with the depth of invasion ( P = 0.0259), the nodal status ( P < 0.0001), distant metastasis ( P = 0.0354), the stage ( P < 0.0001) and poor disease-free survival ( P = 0.003). Multivariate Cox regression analysis showed that VAV3 overexpression is an independent prognostic marker for CRC ( P = 0.041). In vitro experiments indicated that VAV3 knockdown inhibited CRC cell growth, spread and xenograft proliferation. Mechanistic studies further revealed that VAV3 overexpression could dysregulate the expression of cell cycle control- and metastasis-related molecules by activating the PI3K-AKT signaling pathway in both CRC cells and xenografts. This study suggests that VAV3 overexpression could be a useful marker for predicting the outcomes of CRC patients and that VAV3 targeting represents a potential modality for treating CRC. 其他題名： Sci Rep 出版者： London: Nature Publishing Group UK 出版日期： 2015-03-20 出處： Scientific reports, 2015-03, Vol.5 (1), p.9360, Article 9360 資源來源： Publicly Available Content Database (Proquest) 版權： The Author(s) 2015 版權： Copyright Nature Publishing Group Mar 2015 版權： Copyright © 2015, Macmillan Publishers Limited. All rights reserved 2015 Macmillan Publishers Limited. All rights reserved 識別號： ISSN: 2045-2322 識別號： EISSN: 2045-2322 識別號： DOI: 10.1038/srep09360 識別號： PMID: 25791293
顯示於類別:	[生命科學系] 期刊論文

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