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| 題名: | 7,7′′-Dimethoxyagastisflavone-induced apoptotic or autophagic cell death in different cancer cells |
| 作者: | 吳忻怡;Hwang, Chia-Hsiang;Lin, Yu-Ling;Liu, Yen-Ku;Chen, Chia-Hung;Wu, Hsin-Yi;Chang, Cheng-Chang;Chang, Chao-Yuan;Chang, Yu-Kuo;Chiu, Yi-Han;Liao, Kuang-Wen;Lai, Yiu-Kay |
| 貢獻者: | 總教學中心通識教育中心 |
| 關鍵詞: | 7,7′′‐dimethoxyagastisflavone;7′′-dimethoxyagastisflavone;Alkaloids;Alkaloids - isolation & purification;Antineoplastic Agents, Phytogenic;Antineoplastic Agents, Phytogenic - isolation & purification;Antineoplastic Agents, Phytogenic - pharmacology;Apoptosis;Autophagy;biflavonoid;Biflavonoids;Biflavonoids - isolation & purification;Biflavonoids - pharmacology;Biological and medical sciences;Biomarkers, Tumor;Biomarkers, Tumor - metabolism;Caspase 3;Caspase 3 - metabolism;Cell Survival;chemistry;Chromatography, High Pressure Liquid;colorectal neoplasms;drug effects;Enzyme Activation;General pharmacology;Hep G2 Cells;hepatoma;HT29 Cells;human cell lines;Humans;Inhibitory Concentration 50;isolation & purification;lung neoplasms;Medical sciences;membrane potential;Membrane Potential, Mitochondrial;metabolism;Mitochondria;Mitochondria - drug effects;Mitochondria - metabolism;Pharmacognosy. Homeopathy. Health food;pharmacology;Pharmacology. Drug treatments;Taxoids;Taxoids - isolation & purification;Taxus;Taxus - chemistry;Taxus media;Taxus × media cv. Hicksii |
| 日期: | 2012-04-01 |
| 上傳時間: | 2026-04-23 12:52:21 (UTC+8) |
| 出版者: | John Wiley and Sons Ltd;Chichester, UK: John Wiley & Sons, Ltd |
| 摘要: | 摘要： 7,7′′‐Dimethoxyagastisflavone (DMGF), a biflavonoid isolated from the needles of Taxus × media cv. Hicksii, was evaluated for its antiproliferative and antineoplastic effects in three human cancer cell lines. Interestingly, DMGF caused cell death via different pathways in different cancer cells. DMGF induced apoptosis, activated caspase‐3 activity and changed the mitochondrial membrane potential in HT‐29 human colon cancer cells. However, the apoptotic pathway is not the major pathway involved in DMGF‐induced cell death in A549 human lung cancer cells and HepG2 human hepatoma cells. Treatment with 3‐MA, an inhibitor of autophagy, significantly decreased DMGF‐induced cell death in HepG2 and A549 cells, but did not affect DMGF‐induced cell death in HT‐29 cells. Following DMGF treatment, the HepG2 cells increased expression of LC3B‐II, a marker used to monitor autophagy in cells. Thus, DMGF induced apoptotic cell death in HT‐29 cells, triggered both apoptotic and autophagic death in A549 cells and induced autophagic cell death in HepG2 cells. Copyright © 2011 John Wiley & Sons, Ltd.
其他題名： Phytother. Res
出版者： Chichester, UK: John Wiley & Sons, Ltd
出版日期： 2012-04
出處： Phytotherapy research, 2012-04, Vol.26 (4), p.528-534
資源來源： Wiley Online Library - AutoHoldings Journals
版權： Copyright © 2011 John Wiley & Sons, Ltd.
版權： 2015 INIST-CNRS
識別號： ISSN: 0951-418X
識別號： ISSN: 1099-1573
識別號： EISSN: 1099-1573
識別號： DOI: 10.1002/ptr.3583
識別號： PMID: 21915931 |
| 顯示於類別: | [通識教育中心] 期刊論文
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