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| 題名: | The APOE e{open}4 allele affects complexity and functional connectivity of resting brain activity in healthy adults |
| 作者: | 黃鍔;Yang, Albert C;Huang, Chu-Chung;Liu, Mu-En;Liou, Yin-Jay;Hong, Chen-Jee;Lo, Men-Tzung;Huang, Norden E;Peng, Chung-Kang;Lin, Ching-Po;Tsai, Shih-Jen |
| 貢獻者: | 認知智慧與精準健康照護研究中心 |
| 日期: | 2014-01-01 |
| 上傳時間: | 2026-04-23 14:27:06 (UTC+8) |
| 出版者: | San Antonio: John Wiley & Sons, Inc |
| 摘要: | 摘要： The apolipoprotein E (APOE) gene is associated with structural and functional brain changes. We have used multiscale entropy (MSE) analysis to detect changes in the complexity of resting blood oxygen level-dependent (BOLD) signals associated with aging and cognitive function. In this study, we further hypothesized that the APOE genotype may affect the complexity of spontaneous BOLD activity in younger and older adults, and such altered complexity may be associated with certain changes in functional connectivity. We conducted a resting-state functional magnetic resonance imaging experiment in a cohort of 100 younger adults (aged 20-39 years; mean 27.2±4.3 years; male/female: 53/47) and 112 older adults (aged 60-79 years; mean 68.4±6.5 years; male/female: 54/58), and applied voxelwise MSE analysis to assess the main effect of APOE genotype on resting-state BOLD complexity and connectivity. Although the main effect of APOE genotype on BOLD complexity was not observed in younger group, we observed that older APOE 4 allele carriers had significant reductions in BOLD complexity in precuneus and posterior cingulate regions, relative to noncarriers. We also observed that reduced BOLD complexity in precuneus and posterior cingulate regions was associated with increased functional connectivity to the superior and inferior frontal gyrus in the older group. These results support the compensatory recruitment hypothesis in older APOE 4 carriers, and confer the impact of the APOE genotype on the temporal dynamics of brain activity in older adults. Hum Brain Mapp 35:3238-3248, 2014. © 2013 Wiley Periodicals, Inc. [PUBLICATION ABSTRACT]
出版者： San Antonio: John Wiley & Sons, Inc
出版日期： 2014-07-01
出處： Human brain mapping, 2014-07, Vol.35 (7), p.3238-3248
資源來源： Alma/SFX Local Collection
版權： Copyright © 2013 Wiley Periodicals, Inc.
識別號： ISSN: 1065-9471
識別號： EISSN: 1097-0193
識別號： DOI: 10.1002/hbm.22398 |
| 顯示於類別: | [認知智慧與精準健康照護研究中心] 期刊論文
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