抗菌脂肽與類細菌脂質膜在最低抑制濃度下的相互作用;Interactions between antimicrobial lipopeptides and bacteria-mimetic lipid membranes across the minimum inhibitory concentrations

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Title:	抗菌脂肽與類細菌脂質膜在最低抑制濃度下的相互作用;Interactions between antimicrobial lipopeptides and bacteria-mimetic lipid membranes across the minimum inhibitory concentrations
Authors:	陳冠倫;Chen, Guan-Lun
Contributors:	化學工程與材料工程學系
Keywords:	抗菌脂肽;最小抑菌濃度;彈性自由能;antimicrobial lipopeptides;minimum inhibitory concentration;elastic free energy
Date:	2022-09-29
Issue Date:	2022-10-04 11:02:27 (UTC+8)
Publisher:	國立中央大學
Abstract:	細菌的抗生素耐藥性是對治療的威脅。科學家們希望找到一種替代療法來解決這個問題。抗菌脂肽被認為是替代傳統抗生素的有潛力療法，因為它們對細菌耐藥性的敏感性較低。在最小抑菌濃度抗菌成本較低，我們的實驗選擇最小抑菌濃度來研究抗菌脂肽彈性性質的變化。更具體地說，透過動態光散射儀、螢光光譜儀和小角度 X 光散射實驗，我們研究不同的抗菌脂肽如何改變彈性和結構特性，包括彎曲係數、自發曲率（即彎曲趨勢）和脂質膜的厚度。實驗結果指出在最小抑菌濃度下抗菌脂肽對於單層囊泡的彈性性質，彎曲係數、自發曲率和膜厚無明顯變化，並且彈性自由能也沒有顯著差異。;Antibiotic resistance of bacteria is a threat to treatment. Scientists want to find an alternative therapy to solve this issue. Antimicrobial lipopeptides have been considered as a promising alternative to conventional antibiotics, due to their lower vulnerability to bacterial drug resistance. Our experiment chose the MIC (minimum inhibitory concentration) to investigate the change of elastic properties in antimicrobial lipopeptide for lower cost. More specifically, by dynamic light scattering, fluorescent spectroscopy, and small-angle X-ray scattering, we examine how the different antimicrobial lipopeptides alter the elastic and structural properties, including bending stiffness, spontaneous curvature (i.e., the tendency of curving) and membrane thickness of the membranes. The results of the experiment pointed out that the elastic property bending stiffness, spontaneous curvature and membrane thickness not changed significantly in MIC, and there is no significant difference in the elastic free energy.
Appears in Collections:	[National Central University Department of Chemical & Materials Engineering] Electronic Thesis & Dissertation

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