;During the construction phase of building projects, multiple trades often work simultaneously and high-risk operations overlap. If safety measures fail to integrate these risks, the likelihood of accidents increases. This study focuses on large-scale building projects in Taiwan and develops a work-safety management effectiveness framework based on six dimensions: work-at-height fall prevention, welding and hot work, temporary electricity and electric-shock prevention, structural support and excavation, underground space operations, and machinery operation. A structured questionnaire survey was conducted with professionals experienced in construction and occupational safety and health, yielding 252 valid responses on a five-point Likert scale. Reliability and validity were examined within a structural equation modeling framework, and structural relationships were estimated using multiple regression. Model explanatory power was evaluated using R² and f². Results show that all six dimensions have mean scores around the “agree” level, indicating generally positive perceptions of current safety management. Machinery operation has the strongest positive effect on overall work-safety management effectiveness, and temporary electricity and electric-shock prevention is also statistically significant. The other dimensions are not significant, while the model explains about 73% of the variance in work-safety management effectiveness (R² ≈ 0.73). Based on these findings, the study identifies management priorities and proposes practical improvement strategies for the six dimensions to support safety management in building construction projects.