以生理資料為基礎的心血管系統模型之建構

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姓名

陳佳俊(Chia-chun Chen) 查詢紙本館藏

畢業系所

電機工程學系

論文名稱

以生理資料為基礎的心血管系統模型之建構
(Cardiovascular system modeling based on the physiology data)

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摘要(中)

心血管系統模型的用途十分廣泛，常運用在臨床診斷、藥品測試和醫療儀器開發等方面。本研究的目的是以生理資料為基礎建構心血管系統模型，根據生理文獻上的資料將模型中的血管阻力與順應性以等效的電路元件來模擬，進行多個週期的模擬及觀察模擬的結果。除此之外，在模型中加入神經系統的調控，使模型可模擬交感神經對心室體積與血管阻抗的監控，以達到維持血壓的功能。除了模擬正常情況下的生理現象，我們也做了其他兩種病態的模擬，此兩種病態分別為主動脈瓣膜狹窄與僧帽瓣膜狹窄。從結果顯示本論文的心血管系統模型可以成功模擬出正常時的右心臟、左心臟和其它部位血管的血壓以及瓣膜異常的病理特徵，比較模擬結果和文獻與生理書上的資料
，驗證系統模型在模擬上的可行性。

摘要(英)

The cardiovascular system models could be widely used in clinical diagnosis, drug testing, development of medical instrumentation, and so on. The purpose of this study is to build a cardiovascular system model based on the physiological data. The equivalent circuit elements were used to model the resistance and compliance of the vascular system, implement the multi-cycle simulation, and observe the simulated results. Furthermore, the neural control was added to regulate simulation of the model. This neural control provided simulation of the autonomic regulation on the blood pressure through the ventricular volume and vascular resistance. In addition to the simulation of normal condition, the model was used to simulate two pathological conditions, i.e., aortic and mitral valve stenoses. Comparison between the results of our simulation and previous literature studies, our results showed that this cardiovascular system model was capable to simulate normal blood pressure of right heart, left heart, other parts of the blood vessels, and pathological features of valve stenosis and indicated its feasibility as a cardiovascular system model.

關鍵字(中)

★ 心血管系統模型
★ 模擬
★ 主動脈瓣膜狹窄
★ 僧帽瓣膜狹窄

關鍵字(英)

★ Cardiovascular System
★ Simulation
★ Aortic Stenosis
★ Mitral Stenosis

論文目次

目錄
摘要 I
Abstract II
致謝 IV
目錄 IV
圖目錄 VI
第一章緒論 1
1.1研究動機 1
1.2文獻探討 5
1.3 論文架構 12
第二章心血管系統介紹 14
2.1心血管系統架構 14
2.2心血管疾病 22
第三章心血管循環系統模型 25
3.1心血管系統模型的建構 25
3.2心血管系統模型的參數 36
3.3心血管系統模型的模擬 41
3.3.1 正常情況 41
3.3.3 僧帽瓣膜狹窄 44
第四章自主神經控制與血壓控制 48
4.1自主神經系統 48
4.2自主神經系統自動切換 58
第五章結果與討論 62
5.1正常狀況的模擬結果 62
5.2主動脈瓣膜狹窄的模擬結果 67
5.3 僧帽瓣膜狹窄的模擬結果 72
5.4討論 76
第六章結論與未來展望 88
6.1 結論 88
6.2 未來展望 89
文獻參考 90
附錄A 94

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指導教授

吳炤民(Chao-Min Wu)

審核日期

2013-8-26

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