| dc.description.abstract |
According to the Health Promotion Administration (HPA), the incidence rate and mortality rate of women breast cancer increase gradually in Taiwan within a decade. X-ray mammography has been used as a standard for breast screening and early diagnosis, but still exists fairly misdiagnosis rate due to the limitation of its structural images, especially for its relatively low sensitivity. Near infrared diffuse optical tomography (NIR DOT), a functional medical imaging modality, has been exploited to reconstruct optical-property images of tissues since middle 1990’s.
In this study, we developed and validated a diffuse optical imaging module with using compressive paddles of parallel scanning. The NIR DOT system deployed an intensity-modulated (at 20 MHz) laser diodes with 830 nm. The system used two parallel-paddles with dual-direction scanning modules, which measured breast-like phantoms to acquire both amplitude and phase information of out-emitted transmittance and reflection NIR in the both up-down and down-up directions. Then, to verify the system performance, we used reconstruction program, NIRFD_PC, which developed by our D-BioM laboratory to read and processed the measure data. The experiment results identified thickness of phantom and tumor-like phantom size, position and contrast of optical coefficient. For absorption coefficient image, we couldn’t identify diameter and contrast μa of tumor is less than 5 mm and 1.5 respectively. For scattering coefficient image, we couldn’t identify diameter and contrast μs‘ of tumor is less than 15 mm and 0.89 respectively. After, we conducted clinical trial with Tao-Yuan General Hospital (TYGH). We installed NIR DOT system which compatible with the apparatus of X-ray mammography to measure right and left breast of participants and compared X-ray mammography with optical coefficient image. As the result of clinical trial, our system could identify the relatively position of extremely dense glandular and adipose tissue and diameter of tumor is more than 15 mm on the absorption and scattering coefficient image. In the future, NIR DOT system is used to screen breast and may increase the rate of recognition for tumor. | en_US |