| DC 欄位 |
值 |
語言 |
| DC.contributor | 化學學系 | zh_TW |
| DC.creator | 吳昱諄 | zh_TW |
| DC.creator | Yu-Chun Wu | en_US |
| dc.date.accessioned | 2019-8-22T07:39:07Z | |
| dc.date.available | 2019-8-22T07:39:07Z | |
| dc.date.issued | 2019 | |
| dc.identifier.uri | http://ir.lib.ncu.edu.tw:444/thesis/view_etd.asp?URN=106223056 | |
| dc.contributor.department | 化學學系 | zh_TW |
| DC.description | 國立中央大學 | zh_TW |
| DC.description | National Central University | en_US |
| dc.description.abstract | 以辛可寧衍生出的掌性催化劑促成多種2-吡啶酮與a,b-不飽和酮進行
不對稱1,4 加成反應，其中以辛可寧的方醯胺衍生物可以得到高產
率及鏡像選擇性，產率可達98%，鏡像選擇性可達99%。並且應用
2-吡啶酮與苯甲醯丙烯酸乙酯進行麥可加成反應後的產物，可以合
成出具有光學活性的人類鼻病毒3C 蛋白酶抑制劑前驅物。 | zh_TW |
| dc.description.abstract | The enantioselective organocatalytic aza-Michael addition of 2-hydroxypyridines (pyridin-2(1H)-ones) to a,b-unsaturated 1,4-diones to yield chiral N-substituted 2-pyridones is reported. The reactions were optimized by the choice of solvents and screening a series of cinchonine catalysts to achieve good yields and enantioselectivities (up to 98% yield and >99% ee). Finally using Michael product completed the synthesis to precursor of Human Rhinovirus 3C Protease Inhibitors through a series of reaction. | en_US |
| DC.subject | 有機催化 | zh_TW |
| DC.subject | 2-吡啶酮 | zh_TW |
| DC.title | 有機催化 2-吡啶酮與 苯甲醯丙烯酸乙酯進 行具鏡像選擇之加成反應 | zh_TW |
| dc.language.iso | zh-TW | zh-TW |
| DC.type | 博碩士論文 | zh_TW |
| DC.type | thesis | en_US |
| DC.publisher | National Central University | en_US |