| dc.description.abstract | Nanobiohybrids, synthesized by integrating functional nanomaterials with living systems, have emerged as a novel branch of research at the interface of materials engineering and biological science. Nanobiohybrids use synthetic nanomaterials to overcome harsh environmental problems and impart organisms with emergent properties. Among all materials, Metal-organic Frameworks (MOFs) is a novel material made from metal ions and organic linkers. MOFs have consistent pore properties, large surface area, thermo-chemical stability, catalyzing, etc through the adjustment of the precursors. Therefore, the development of the combination of Metal-organic frameworks and living systems is rapidly emerging.
The prokaryotic living cell Escherichia coli (E. coli) for the first time is encapsulating into a single crystalline particle of Metal-organic Frameworks via de novo approach to create a novel biocomposite of “cyborgcells”. In the de novo approach, E. coli is entirely armored with single-crystalline ZIF-90 microporous in a single macro-size particle for the completely size-shielding protection, and therefore E. coli can be survived even lethal antibiotic treatment.
By comparison with ZIF-8, the poly-crystalline multiple-nanoparticles are formed in surrounding on E. coli surface as their higher zeta potential differences, but with poor antibiotic protection. We hope that this model may pave the way to new avenues for the transportation and storage of living systems, cell immobilization, biosensing. | en_US |