| DC 欄位 |
值 |
語言 |
| DC.contributor | 化學學系 | zh_TW |
| DC.creator | 馮家琪 | zh_TW |
| DC.creator | Chia-Chi Feng | en_US |
| dc.date.accessioned | 2021-8-30T07:39:07Z | |
| dc.date.available | 2021-8-30T07:39:07Z | |
| dc.date.issued | 2021 | |
| dc.identifier.uri | http://ir.lib.ncu.edu.tw:444/thesis/view_etd.asp?URN=108223017 | |
| dc.contributor.department | 化學學系 | zh_TW |
| DC.description | 國立中央大學 | zh_TW |
| DC.description | National Central University | en_US |
| dc.description.abstract | Nabscessin C (1)是從市售的肌醇(myo-inositol)與原甲酸三乙酯(triethyl orthoformate)經由12步合成出來。肌醇原酸酯化合物81，其具有兩個軸向羥基和一個赤道羥基，這個特徵有助於更好地區分原酸酯的羥基。
此合成主要是利用肌醇(myo-inositol)原有的六元環架構，將環上羥基進行脫氧(deoxygenation)以及還原胺化反應(reductive amination)使羥基轉換為胺基生成碳氮鍵，得到其關鍵中心脫氧胺基鯊肌醇(2-deoxy-scyllo-inosamine, DOIA)來合成目標產物。 | zh_TW |
| dc.description.abstract | We synthesize from commercial available myo-inositol and triethyl orthoformate. The myo-inositol orthoester has two axial hydroxyl and one equatorial hydroxyl group and this feature facilitates better discrimination among the hydroxyl groups of orthoesters.
We use the structure of myo-inositol and subsequent transformations, including deoxygenation and reductive amination, to provide the key 2-deoxyscylla inosine core (DOIA) to complete the synthesis of Nabscessin C (1). | en_US |
| DC.subject | 全合成 | zh_TW |
| DC.title | Nabscessin C的全合成 | zh_TW |
| dc.language.iso | zh-TW | zh-TW |
| DC.type | 博碩士論文 | zh_TW |
| DC.type | thesis | en_US |
| DC.publisher | National Central University | en_US |