| DC 欄位 |
值 |
語言 |
| DC.contributor | 化學學系 | zh_TW |
| DC.creator | 陳韋辰 | zh_TW |
| DC.creator | Wei-Chen Chen | en_US |
| dc.date.accessioned | 2021-10-28T07:39:07Z | |
| dc.date.available | 2021-10-28T07:39:07Z | |
| dc.date.issued | 2021 | |
| dc.identifier.uri | http://ir.lib.ncu.edu.tw:444/thesis/view_etd.asp?URN=108223036 | |
| dc.contributor.department | 化學學系 | zh_TW |
| DC.description | 國立中央大學 | zh_TW |
| DC.description | National Central University | en_US |
| dc.description.abstract | 本論文以芳樟醇和香葉醇作為起始物，經果兩步驟反應，得到了有手性的噁唑烷酮稠合吖環丙烷，再將這些吖環丙烷進行鹵素開環，可以得到單一的鏡像化合物，並且有良好的選擇性和產率。將此策略應用於合成 3-[18F]FV，由於氟的胺基酸 3-[18F]FV可作為腫瘤的快速示踪劑，在腫瘤學上是一大突破。因此合成 3-[18F]FV 為本論文致力研究的目標產物。我們使用天然物 L-阿拉伯醣進行多步驟的反應得到烯類化合物，再以此烯類化合物進行多步驟反應生成噁唑烷酮稠合吖環丙烷。最後，進行鹵素開環得到單一的鏡像化合物，並且有良好的選擇性，此部分目前只研究到這，我們之後會努力完成它。 | zh_TW |
| dc.description.abstract | In this paper, linalool and geraniol were used as starting materials, and the chiral oxazolidinone fused aziridine was obtained through a two-step reaction. These oxazolidinone fused aziridine are then subjected to halogen ring opening, and a single chiral compound can be obtained with good selectivity and yield. Applying this strategy to the synthesis of 3-[18F]FV, because the amino acid 3-[18F]FV can be used as a rapid tracer of tumors, it is a breakthrough in oncology. Therefore, the synthesis of 3-[18F]FV is the target product of this thesis. We use natural L-arabinose to carry out a multi-step reaction to obtain olefinic compounds, and then use this olefinic compound to carry out a multi-step reaction to generate oxazolidinone fused aziridine . Finally, the halogen ring is opened to obtain a single chiral compound with good selectivity. This part is currently only studied, and we will work hard to complete it. | en_US |
| DC.subject | 噁唑烷酮稠合吖環丙烷 | zh_TW |
| DC.subject | oxazolidinone fused aziridine | en_US |
| DC.title | 噁唑烷酮稠合吖環丙烷之鹵素開環反應研究 | zh_TW |
| dc.language.iso | zh-TW | zh-TW |
| DC.type | 博碩士論文 | zh_TW |
| DC.type | thesis | en_US |
| DC.publisher | National Central University | en_US |