| dc.description.abstract | The purpose of this study was to prepare a curcuminoid-loaded liposome solution through the thin film hydration method to encapsulate curcuminoid in the liposomes to prevent curcuminoid from being decomposed at high temperature and light, and to improve the solubility of curcuminoid in water, thereby enhancing the bioavailability. In this study, emulsifiers such as tween 80, tween 20, tween 80/span80, and tween80/span 85, as well as phosphatidylcholine and cholesterol, were used as liposome coating materials. Furthermore, ethanol was used as a solvent, instead of chloroform in the traditional method, to form a spherical bimolecular phospholipid layer membrane. In this study, different ratios and types of emulsifiers were used to prepare liposome solutions, and the samples were stored at 4℃ to test their stability. Furthermore, select samples with good encapsulation efficiency and place them at room temperature and 40℃ for stability testing. Finally, the samples with the best encapsulation efficiency were selected for scale-up testing to test the commercialization potential of curcuminoid-loaded liposome solution. UV-visible-near-infrared spectroscopy was used to measure the concentration of curcuminoid liposomes, and to determine the encapsulation efficiency and total curcuminoid concentration. The dynamic light scattering was used for particle size measurement, and its appearance was observed with an optical microscope and transmission electron microscopy. The best preparation condition was phosphatidylcholine: cholesterol: tween 80 = 4: 1: 50, and the sample was very stable after 100 days of storage. | en_US |