| DC 欄位 |
值 |
語言 |
| DC.contributor | 化學學系 | zh_TW |
| DC.creator | 吳勁勳 | zh_TW |
| DC.creator | Chin-Hsun Wu | en_US |
| dc.date.accessioned | 2022-9-29T07:39:07Z | |
| dc.date.available | 2022-9-29T07:39:07Z | |
| dc.date.issued | 2022 | |
| dc.identifier.uri | http://ir.lib.ncu.edu.tw:444/thesis/view_etd.asp?URN=109223031 | |
| dc.contributor.department | 化學學系 | zh_TW |
| DC.description | 國立中央大學 | zh_TW |
| DC.description | National Central University | en_US |
| dc.description.abstract | 本論文的目標為合成KRN7000衍生物。以對稱雙烯醇為起始物進行夏普萊斯不對稱環氧化反應 (Sharpless asymmetric epoxidation) 生成含有兩個立體中心的環氧化合物，再利用十二烷基格林納試劑 (Grignard reagent) 對其進行開環反應延伸碳鏈。接著以高效率微波加熱的方式進行吖環丙烷化反應 (stereoselective aziridination) 建立第三個立體中心並具良好的非鏡像選擇性。其關鍵步驟是以肌醇衍生物對吖環丙烷進行開環反應生成碳氧鍵。最後經由數步反應得到目標產物。 | zh_TW |
| dc.description.abstract | Sharpless asymmetric epoxidation was carried out with a symmetric dienol as the starting material to generate a chiral epoxide containing two stereocenters. The carbon chain was elongated by the ring-opening reaction with dodecyl Grignard reagent. The third stereocenter is established by a diastereoselective aziridination reaction, assisted with highly-efficient microwave heating. The most critical step is to conduct the aziridine ring-opening reaction with an inositol derivative to generate the carbon-oxygen bond, and then obtain the target product KRN7000 derivative through several transformations. | en_US |
| DC.subject | 噁唑烷酮稠合吖環丙烷 | zh_TW |
| DC.subject | 羥基開環反應 | zh_TW |
| DC.subject | 肌醇衍生物 | zh_TW |
| DC.title | 噁唑烷酮稠合吖環丙烷進行羥基開環反應與KRN7000環己醇類似物之合成研究 | zh_TW |
| dc.language.iso | zh-TW | zh-TW |
| DC.title | Hydroxyl Group Ring-Opening of Oxazolidinone Fused Aziridine and Synthesis of KRN7000 analogue | en_US |
| DC.type | 博碩士論文 | zh_TW |
| DC.type | thesis | en_US |
| DC.publisher | National Central University | en_US |