| DC 欄位 |
值 |
語言 |
| DC.contributor | 化學學系 | zh_TW |
| DC.creator | 彭御鈞 | zh_TW |
| DC.creator | Yu-Chun Peng | en_US |
| dc.date.accessioned | 2022-9-29T07:39:07Z | |
| dc.date.available | 2022-9-29T07:39:07Z | |
| dc.date.issued | 2022 | |
| dc.identifier.uri | http://ir.lib.ncu.edu.tw:444/thesis/view_etd.asp?URN=109223045 | |
| dc.contributor.department | 化學學系 | zh_TW |
| DC.description | 國立中央大學 | zh_TW |
| DC.description | National Central University | en_US |
| dc.description.abstract | 本篇論文的目標為合成天然物17-Hydroxymandarone B。在此合成中，我們簡化了之前的合成步驟，使得合成前驅物11更有效率。
另外在本合成中有一氫化反應會形成非鏡像異構物的混合物，化合物13。但此非鏡像異構物的混合物無法藉由管柱層析分離，使的本合成無法得到單一組態的17-Hydroxymandarone B。
我們發現將混合物14與掌性輔助劑反應後，所得之非鏡像異構物的混合物可以藉由管柱層析有效分離。得到與天然物17-Hydroxymandarone B立體中心相同的中間物，並繼續進行天然物17-Hydroxymandarone B的合成研究。 | zh_TW |
| dc.description.abstract | The natural product 17-Hydroxymandarone B is the target molecular in this thesis. In this synthesis, we simplified the previous synthetic steps and made the synthesis of compound 11 more efficient.
In addition, a hydrogenation reaction in this synthesis formed a mixture of diastereoisomers. However, the mixture of diastereomers could not be separated by column chromatography, so pure 17-Hydroxymandarone B could not be obtained in the end.
We found that by reacting the above mixture with a chiral auxiliary, the resulting diastereoisomers were efficiently separated by column chromatography. The intermediate possesses the same stereocenters with the natural 17-Hydroxymandarone B, and the synthesis of the natural 17-Hydroxymandarone B could be continued. | en_US |
| DC.subject | 掌性輔助劑 | zh_TW |
| DC.subject | 脱氫松香胺 | zh_TW |
| DC.subject | 夫-夸醯化反應 | zh_TW |
| DC.title | 17-Hydroxymandarone B 合成之進展 | zh_TW |
| dc.language.iso | zh-TW | zh-TW |
| DC.title | Progress in the Synthesis of 17-Hydroxymandarone B | en_US |
| DC.type | 博碩士論文 | zh_TW |
| DC.type | thesis | en_US |
| DC.publisher | National Central University | en_US |