| dc.description.abstract | Fibrosis is a process of tissue repair that can be difficult to reverse due to dysregulation during the repair process. It develops in liver tissue as a result of chronic inflammation. The process of fibrosis is highly complex, involving various chemical factors and mechanical stress regulation, and it often occurs concomitantly with many diseases. In this study, transcriptomic data from cell cultures, as well as mouse and rat models, stimulated by physical and chemical stimuli, were analyzed. In this study, transcriptomic data from cell cultures, as well as mouse and rat models, stimulated by physical and chemical stimuli, were analyzed. Immuno composition analysis was performed to confirm the immune characteristics within the models. Differential expression genes were filtered based on the condition of |log2FC| > 1 and used for pathway analysis. Many pathways related to fibrosis, such as cell cycle regulation, immune regulation, tissue repair, ECM structural changes, and others, were discovered. Additionally, it was observed that models stimulated using different methods significantly participated in different pathways. The features displayed in various models differ, and potential regulatory factors have been proposed in the analysis of different stages. These data can provide valuable information for selecting a suitable approach when constructing different fibrosis models. | en_US |