| dc.description.abstract | In order to avoid skin damage and skin cancer caused by long-term sun exposure, it is very important to use sunscreen products. Benzophenones (BPs) are the main sunscreen ingredients because these compounds can absorb ultraviolet radiations, so they are widely used in personal care products and packaging to prevent skin or products from being harmed and degraded by ultraviolet radiations. However, in recent years, many studies have found that BPs are cumulative and presistent in the environment, and have adverse effects on the ecosystem, thereby possibly affecting animals endocrine, reproductive and other dysfunctional diseases.
In this study, we developed a cross-linked poly ionic liquid as an adsorbent material for the dispersive micro-solid extraction (DmSPE) method to extract BPs residues in environmental water samples. An imidazole-based polyionic liquid with a hydrophobic characteristic structure was prepared, which can be stable in water and at high temperatures. After cross-linking, the adsorbent can be significantly strengthened and have more powerful extraction efficiency, therefore effectively extracting BPs residues from environmental water samples. Then, ultra-high performance liquid chromatography electrospray ionization(+)-quadrupole time-of-flight mass spectrometry(UHPLC-ESI(+)-QTOF-MS) was applied for identification and quantification, and the signal-to-noise ratio was increased through high-resolution extraction ion chromatograms (hrXIC) technique.
The DmSPE method was then optimized by experimental design Box-Behnken Design (BBD) analysis, the optimization conditions were: using 25.0 mg poly ionic liquid P(C12VImPF6)DVB as the adsorbent material, added to 10 mL water sample, and vortex for 5 minutes for extraction, centrifuged for 5 minutes, the desorption solvent was 1 mL of 70% methanol, vortex for 1 minute for desorption, then concentrated to 0.1 mL by nitrogen blowing, and finally 3 μL of the extract was injected into UHPLC-QTOF-MS for analysis. The precision (RSD) of the extraction method was all less than 5%, the extraction recoveries was between 62% and 148%, the linearities of R2 was large than 0.9956, indicating good repeatability, accuracy, and linearity of the method. The limits of detection (LOD) and limits of quantification (LOQ) of the method ranged between 0.10.3 ng/mL and 0.41.5 ng/mL, respectively. | en_US |