| dc.description.abstract | To expand the applications of matrix-assisted laser desorption/ ionization time-of-flight mass spectrometry (MALDI-TOF-MS) in the field of small molecules detection, in this study, we successfully synthesized metal organic frameworks (MOFs) MIL-101 (Cr) by solvent-free method, and applied MIL-101 (Cr) as the adsorbent for dispersive micro solid-phase extraction (DmSPE), and then, the MIL-101 can be directly applied as matrix for MALDI-TOF-MS to determine benzophenones (BPs) residues in environmental water samples. We explore the application of MIL-101 (Cr) as both the adsorbent and matrix for MALDI for the enrichment and analysis of BPs. The developed method reduced the steps of analysis, i.e., no solvent desorption, and speed-up the multi-target analytes detection, i.e., no chromatography.
Four key experimental conditions were evaluated and optimized, such as, the adsorbent amount, extraction time, pH value of water sample, and dispersive solvent used. After
optimization, the limits of detection (LOD) of the method ranged between 0.020-0.2 mM. Precision was evaluated using intra-day and inter-day analyses, with relative standard
deviations (RSD) of all below 6%, and R2 of linearities were large than 0.9674, indicating good repeatability and linear relationship of the method. The extraction recovery rates in real environmental water samples were between 67% and 96%, and the RSD were less than 6%, showing that the method has a good recovery and repeatability rates in environmental water
samples. In short, we developed an analytical method for the rapid detection of BPs residues in environmental water samples by coupling with MOF, DmSPE and MALDI-TOF-MS, and
moreover, successfully expanded the application of MALDI-TOF-MS in small molecules detection. | en_US |