博碩士論文 90223005 完整後設資料紀錄

DC 欄位	值	語言
DC.contributor	化學學系	zh_TW
DC.creator	蔡宗衛	zh_TW
DC.creator	Chung-Wel Tsai	en_US
dc.date.accessioned	2004-1-27T07:39:07Z
dc.date.available	2004-1-27T07:39:07Z
dc.date.issued	2004
dc.identifier.uri	http://ir.lib.ncu.edu.tw:444/thesis/view_etd.asp?URN=90223005
dc.contributor.department	化學學系	zh_TW
DC.description	國立中央大學	zh_TW
DC.description	National Central University	en_US
dc.description.abstract	摘要 許多疾病被研究證時與 PTP 在人體的作用機制失衡有關，例如第二型糖尿病便是與 PTP-1B 有關的典型例子。 因而，我们利用固相組合式化學成功設計出一套可快速合成具四種不同變化取代的 5,6-Dihydro-pyran-2-one 及其衍生物，以期能找到成功模擬 PTP-1B 在生物體中所扮演的角色，並在我们設計的分子中加入不同的 Binding site，希望能提高其對 PTP-1B 的專一性，並對藥物發展作出貢獻。	zh_TW
dc.description.abstract	ABSTRACT There is evidence that type II diabetes has a connection with insulin resistance. Protein tyrosine phosphatase 1B(PTP 1B) attenuates insulin signal transduction by catalyzing the dephosphorylation of the insulin receptors(IR) and is thus a vital target of potenyial drugs for treatment of type II diabetes. A peptidomimetic sequence targeting at the binding site on PTP1B combined with a suicide inhibition function is the central concept of our design of potential PTP1B inhibitors. A mini library of 5,6-Dihydro-pyran-2-ones was synthesized by a highly efficient scheme which is applicable both in solution-phase synthesis and solid-phase combinatorial synthesis. C-C single bond formation by a stereoselective carbonyl addition gives well-defined stereochemistry in our skeleton and ring closing metathasis(RCM) was applied to afford the dihydropyranone lactone.	en_US
DC.subject	組合式化學	zh_TW
DC.subject	蛋白質酪胺酸磷酸酶	zh_TW
DC.subject	PTP	en_US
DC.subject	solid phase	en_US
DC.subject	chemistry	en_US
DC.title	合成新穎非可逆擬胜肽小分子蛋 白質酪胺酸磷酸酶 1B 抑制劑	zh_TW
dc.language.iso	zh-TW	zh-TW
DC.title	Synthesis of a novel Small Molecular Weight Peptidomimetic non-competitive Inhibitors of Protein Tyrosine Phosphatase 1B	en_US
DC.type	博碩士論文	zh_TW
DC.type	thesis	en_US
DC.publisher	National Central University	en_US