| DC 欄位 |
值 |
語言 |
| DC.contributor | 化學學系 | zh_TW |
| DC.creator | 余聖潔 | zh_TW |
| DC.creator | Sheng-Chieh Yu | en_US |
| dc.date.accessioned | 2005-3-23T07:39:07Z | |
| dc.date.available | 2005-3-23T07:39:07Z | |
| dc.date.issued | 2005 | |
| dc.identifier.uri | http://ir.lib.ncu.edu.tw:444/thesis/view_etd.asp?URN=91223051 | |
| dc.contributor.department | 化學學系 | zh_TW |
| DC.description | 國立中央大學 | zh_TW |
| DC.description | National Central University | en_US |
| dc.description.abstract | 本論文為，探討1,3-偶極環化加成反應的應用。在第一部份的目標為合成嚴重呼吸道症候群（Severe Acute Respiratory Syndrome，SARS）冠狀病毒或其他病毒的抑制劑。利用一號位置為β位向的疊氮基核醣與不同的末端炔類進行1,3-偶極環化加成反應，得到60個分子進行篩檢。在第二部份為開發新的晶片表面化學方法，將晶片種上炔類後，再利用1,3-偶級環化加成反應將含有疊氮基的各種小分子種在晶片表面上，以利於作各種檢測的工作。 | zh_TW |
| dc.description.abstract | In this thesis, new application of 1,3-dipolar cycloaddition in the synthesis of nucleotides analogue and preparation of biomolecule microarray were developed. In the first section, a nucleotides library with 60 members were created as inhibitors of SARS coronaviruses or another viruses. By using 1, 3-dipolar cycloaddition, different terminal alkynes reacted with ribofuranosyl azide to give the nucleotides library. In the second section , a new methodology was developed to immobilize small organic molecules on glass slide. The azido compounds were implanted on chip surface with alkyne functionality by 1,3-dipolar cycloaddition. | en_US |
| DC.subject | 3-偶極環化加成反應的應用 | zh_TW |
| DC.subject | 1 | zh_TW |
| DC.subject | 3-Dipolar Cycloaddition | en_US |
| DC.subject | 1 | en_US |
| DC.title | 1,3-偶極環化加成反應在藥物合成與醣晶片上的應用 | zh_TW |
| dc.language.iso | zh-TW | zh-TW |
| DC.title | Application of 1, 3-Dipolar Cycloaddition in Drug Discovery and Sugar Microarray | en_US |
| DC.type | 博碩士論文 | zh_TW |
| DC.type | thesis | en_US |
| DC.publisher | National Central University | en_US |